CNOT7

Gene Symbol	CNOT7
Entrez Gene	29883
Alt Symbol	CAF1, Caf1a, hCAF-1
Species	Human
Gene Type	protein-coding
Description	CCR4-NOT transcription complex, subunit 7
Other Description	BTG1 binding factor 1|BTG1-binding factor 1|CAF-1|CCR4-NOT transcription complex subunit 7|CCR4-associated factor 1|carbon catabolite repressor protein (CCR4)-associative factor 1
Swissprots	Q9UIV1 B3KMP1 B3KN35 Q7Z530 D3DSP6 A8MZM5 G3V108
Accessions	CAE90224 EAW63820 EAW63821 EAW63822 EAW63823 Q9UIV1 AA134869 AA165288 AF086915 AAP97145 AK001209 BAG50869 AK021808 BAG51053 AK023466 BAG51197 AK023561 AK090522 AK225893 AL833642 AW448990 BC007315 AAH07315 BC060852 AAH60852 BC070187 AAH70187 BM468592 BT006685 AAP35331 DA752620 L46722 AAF01500 XM_005273481 XP_005273538 XM_011544511 XP_011542813 NM_013354 NP_037486 NM_054026 NP_473367
Function	Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti- proliferative activity. {ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:20634287, ECO:0000269|PubMed:23236473}.
Subcellular Location	Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CNOT7 full length protein - ab162246 from Abcam Category Protein Source Wheat germ Species Human

Human CNOT7 protein fragment - ab162247 from Abcam Category Protein Source Wheat germ Species Human

Mouse CNOT7 full length protein - ab113152 from Abcam Category Protein Source E. coli Species Mouse

CNOT7 Antibody Blocking Peptide - LS-E756 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNOT7 Antibody Blocking Peptide - LS-E14075 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CNOT7 Partial Recombinant Protein - H00029883-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CNOT7 Recombinant Protein - H00029883-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Mouse CNOT7 Protein - NBP1-72420 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli

CAF-1-Antibody-N-term-Blocking-peptide - BP11112a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Mouse CNOT7 protein - orb168138 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Mouse

CNOT7 - H00029883-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CNOT7 - H00029883-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CNOT7 - H00029883-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CNOT7 - H00029883-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CNOT7 fusion protein - ag5508 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CNOT7 fusion protein - Ag5235 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CCR4-NOT transcription complex subunit 7(CNOT7) - CSB-YP883446HU CSB-EP883446HU CSB-BP883446HU CSB-MP883446HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CNOT7 (transcript variant 1) - TP309293 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CCR4-NOT transcription complex subunit 7 (CNOT7), Recombinant Protein - MBS1335161 from MyBioSource Category Protein Prices $1,040.00, $1,040.00, $1,270.00, $1,270.00, $1,615.00, $1,615.00, $2,075.00, $2,075.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human CNOT7 protein - CNOT7-39H from Creative Biomart Category Protein Source E.coli Species Human

CCR4-NOT Transcription Complex, Subunit 7 Protein (Recombinant) - abx261478 from Abbexa Category Protein

CNOT7 Peptide, Human - M34GP03384H from Creative Peptides Category Peptide Source Synthetic. Species Human

CNOT7 Blocking Peptide - CBP5395 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Monkey

CNOT7 Recombinant Protein Antigen - NBP2-57301PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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