| Gene Symbol |
FZD10
|
| Entrez Gene |
11211
|
| Alt Symbol |
CD350, FZ-10, Fz10, FzE7, hFz10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
frizzled class receptor 10
|
| Other Description |
frizzled 10, seven transmembrane spanning receptor|frizzled family receptor 10|frizzled homolog 10|frizzled-10
|
| Swissprots |
Q9ULW2
|
| Accessions |
CAM84938 EAW98507 Q9ULW2 AB027464 BAA84093 AI697875 AL556202 BC070037 AAH70037 BC074997 AAH74997 BC074998 AAH74998 NM_007197 NP_009128
|
| Function |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway
|