| Gene Symbol | FZD10 |
|---|---|
| Entrez Gene | 11211 |
| Alt Symbol | CD350, FZ-10, Fz10, FzE7, hFz10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 10 |
| Other Description | frizzled 10, seven transmembrane spanning receptor|frizzled family receptor 10|frizzled homolog 10|frizzled-10 |
| Swissprots | Q9ULW2 |
| Accessions | CAM84938 EAW98507 Q9ULW2 AB027464 BAA84093 AI697875 AL556202 BC070037 AAH70037 BC074997 AAH74997 BC074998 AAH74998 NM_007197 NP_009128 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |