FZD10
| Gene Symbol | FZD10 |
|---|---|
| Entrez Gene | 11211 |
| Alt Symbol | CD350, FZ-10, Fz10, FzE7, hFz10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | frizzled class receptor 10 |
| Other Description | frizzled 10, seven transmembrane spanning receptor|frizzled family receptor 10|frizzled homolog 10|frizzled-10 |
| Swissprots | Q9ULW2 |
| Accessions | CAM84938 EAW98507 Q9ULW2 AB027464 BAA84093 AI697875 AL556202 BC070037 AAH70037 BC074997 AAH74997 BC074998 AAH74998 NM_007197 NP_009128 |
| Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway |
frizzled-10 CRISPR/Cas9 KO Plasmid (h) - sc-406690 from Santa Cruz Biotechnology
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frizzled-10 HDR Plasmid (h) - sc-406690-HDR from Santa Cruz Biotechnology
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frizzled-10 Double Nickase Plasmid (h) - sc-406690-NIC from Santa Cruz Biotechnology
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frizzled-10 Double Nickase Plasmid (h2) - sc-406690-NIC-2 from Santa Cruz Biotechnology
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frizzled-10 CRISPR Activation Plasmid (h) - sc-406690-ACT from Santa Cruz Biotechnology
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frizzled-10 CRISPR Activation Plasmid (h2) - sc-406690-ACT-2 from Santa Cruz Biotechnology
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frizzled-10 Lentiviral Activation Particles (h) - sc-406690-LAC from Santa Cruz Biotechnology
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frizzled-10 Lentiviral Activation Particles (h2) - sc-406690-LAC-2 from Santa Cruz Biotechnology
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frizzled-10 siRNA (h) - sc-39996 from Santa Cruz Biotechnology
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frizzled-10 shRNA Plasmid (h) - sc-39996-SH from Santa Cruz Biotechnology
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frizzled-10 shRNA (h) Lentiviral Particles - sc-39996-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9023 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9023 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07938 from Sigma-Aldrich
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FZD10 siRNA (Human) - CRH7680 from Cohesion Biosciences
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Frizzled-10 RNAi - H00011211-R02 from Novus Biologicals
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FZD10 - MBS8230449 from MyBioSource
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frizzled-10 CRISPR/Cas9 KO Plasmid (h2) - sc-406690-KO-2 from Santa Cruz Biotechnology
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frizzled-10 HDR Plasmid (h2) - sc-406690-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Fzd10 (NM_007197.3) - SHH298065 from Creative biogene
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Human FZD10 siRNA - orb268182 from Biorbyt
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FZD10 shRNA Plasmid (Human) - CHH7680 from Cohesion Biosciences
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FZD10 miRNA 3'UTR clone - MiUTR3H-08255 from Creative biogene
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