FZD10

Gene Symbol	FZD10
Entrez Gene	11211
Alt Symbol	CD350, FZ-10, Fz10, FzE7, hFz10
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 10
Other Description	frizzled 10, seven transmembrane spanning receptor|frizzled family receptor 10|frizzled homolog 10|frizzled-10
Swissprots	Q9ULW2
Accessions	CAM84938 EAW98507 Q9ULW2 AB027464 BAA84093 AI697875 AL556202 BC070037 AAH70037 BC074997 AAH74997 BC074998 AAH74998 NM_007197 NP_009128
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location	Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Frizzled 10 peptide - ab46353 from Abcam Category Peptide

Human Frizzled 10 protein fragment - ab153168 from Abcam Category Protein Source Wheat germ Species Human

Human Frizzled 10 protein fragment - ab198679 from Abcam Category Protein Source HEK 293 cells Species Human

FZD10 / Frizzled 10 Antibody Blocking Peptide - LS-E28956 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Frizzled-10 Partial Recombinant Protein - H00011211-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Frizzled-10 Recombinant Protein - H00011211-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Recombinant Human Frizzled-10 Fc Chimera, CF - 3459-FZ-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Mouse Frizzled 10 Fc tag protein - orb84065 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Mouse Species Human

Human FZD10 (Fc Tag) protein - orb179629 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human FZD10 (His Tag) protein - orb179630 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

FZD10 Blocking Peptide - 33R-7152 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CD350 / FZD10 / Frizzled-10 - H00011211-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD350 / FZD10 / Frizzled-10 - H00011211-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD350 / FZD10 / Frizzled-10 - H00011211-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FZD10 fusion protein - Ag12867 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

FZD10 fusion protein - Ag12724 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Frizzled Family Receptor 10, Fc-tagged - FZD10-581H from Creative Biomart Category Protein Source Murine myeloma cellline, NS0-derived

Recombinant Human FZD10, GST-tagged - FZD10-13064H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human FZD10, Fc-tagged - FZD10-283H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human FZD10, His-tagged - FZD10-284H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Frizzled Homolog 10 (FZD10) - RPB832Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Frizzled-10 (L164) Peptide - BS2601P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Frizzled-10 Fc Chimera Protein, CF - 3459-FZ from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Human Frizzled-10 (Ile21-Gly161) Accession # Q6NSL8 IEGRMD IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

Human Frizzled-10 / FZD10 Protein (Fc Tag) - 16045-H02H-50 from Sino Biological Category Protein Source Human Cells Species Human

Human Frizzled-10 / FZD10 Protein (His Tag) - 16045-H08H-50 from Sino Biological Category Protein Source Human Cells Species Human

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