FZD10

Gene Symbol FZD10
Entrez Gene 11211
Alt Symbol CD350, FZ-10, Fz10, FzE7, hFz10
Species Human
Gene Type protein-coding
Description frizzled class receptor 10
Other Description frizzled 10, seven transmembrane spanning receptor|frizzled family receptor 10|frizzled homolog 10|frizzled-10
Swissprots Q9ULW2
Accessions CAM84938 EAW98507 Q9ULW2 AB027464 BAA84093 AI697875 AL556202 BC070037 AAH70037 BC074997 AAH74997 BC074998 AAH74998 NM_007197 NP_009128
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
Top Pathways Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

frizzled-10 (G-13) - sc-33511 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

frizzled-10 (C-15) - sc-33513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

frizzled-10 (H-13) - sc-33510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-10 (H-13): sc-33510. Western blot analysis of frizzled-10 expression in rat postnatal kidney tissue extract.

frizzled-10 (H-61) - sc-368103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Frizzled 10 antibody - ab137491 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Frizzled 10 antibody (ab137491) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-Frizzled 10 antibody - ab75291 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Frizzled 10 antibody (ab75291) at 1/500 dilutionLane 1 : Extracts from COS-7 cellsLane 2 : Extracts from COS-7 cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-FZD10 / Frizzled 10 Antibody - LS-C345414 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FZD10 Antibody in COS7 cells transfected with chick FZD10 using Immunofluorescence.

Anti-FZD10 / Frizzled 10 Antibody (aa150-200) - LS-C190812 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD10 / Frizzled 10 Antibody (aa235-495, Biotin) - LS-C297581 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FZD10 / Frizzled 10 Antibody (aa235-495, FITC) - LS-C303530 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FZD10 / Frizzled 10 Antibody (aa36-85) - LS-C101902 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FZD10 / Frizzled 10 antibody LS-C101902 Western blot of HepG2 cell lysate.

Anti-FZD10 / Frizzled 10 Antibody (Leu164) - LS-C177090 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Frizzled-10 (L164) pAb in extracts from COS-7 cells.

Anti-FZD10 / Frizzled 10 Antibody (aa235-495) - LS-C294166 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant FZD10 / Frizzled 10.

Anti-FZD10 / Frizzled 10 Antibody - LS-C47364 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of Frizzled-10 in human brain lysate. Lane 1 shows pre-immune sera and Lanes 2 show LS-C47364 tested on human at 1:1000 dilution.

Anti-FZD10 / Frizzled 10 Antibody (aa135-184) - LS-C120593 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COS7 cells, using FZD10 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-FZD10 / Frizzled 10 Antibody (N-Terminus) IHC-plus™ - LS-A4400 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD10 / Frizzled 10 antibody LS-A4400 IHC of human kidney, fetal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Frizzled-10 Antibody - NBP2-23659 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Frizzled-10 Antibody [NBP2-23659] - Analysis of Frizzled-10 in human brain lysate. Lane 1 shows pre-immune sera and Lanes 2 show NBP2-23659 tested on human at 1:1000 dilution.

Frizzled-10 Antibody - NBP1-85754 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Frizzled-10 Antibody [NBP1-85754] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.

Frizzled-10 Antibody - NBP2-16532 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Frizzled-10 Antibody [NBP2-16532] - Sample (30 ug of whole cell lysate) A: NIH-3T3 B: JC C: BCL-1 7. 5% SDS PAGE gel, diluted at 1:1000.

Frizzled-10 Antibody - NLS4400 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Frizzled-10 Antibody [NLS4400] - Anti-FZD10 / Frizzled 10 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Frizzled 10/CD350 Polyclonal Antibody - bs-13216R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-Frizzled 10/CD350 Polyclonal Antibody, Unconjugated (bs-13216R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Frizzled 10/CD350 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13216R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Frizzled 10/CD350 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13216R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Frizzled 10/CD350 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13216R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Frizzled 10/CD350 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13216R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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