| Gene Symbol |
TFCP2
|
| Entrez Gene |
7024
|
| Alt Symbol |
LBP1C, LSF, LSF1D, SEF, TFCP2C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor CP2
|
| Other Description |
SAA3 enhancer factor|alpha-globin transcription factor CP2
|
| Swissprots |
Q12800 A8K5E9 Q9UD77 Q12801 Q9UD75
|
| Accessions |
AAB29976 EAW58174 EAW58175 EAW58176 EAW58177 EAW58178 Q12800 AK291264 BAF83953 AK308087 AU133131 BC003634 AAH03634 BX479302 M84810 U03494 AAA21324 U03495 AAA21325 NM_001173452 NP_001166923 NM_001173453 NP_001166924 NM_005653 NP_005644
|
| Function |
Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:7828600, ECO:0000269|PubMed:8114710}.
|
| Tissue Specificity |
Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level). {ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:7828600, ECO:0000269|PubMed:8157699}.
|
![Western Blot: CP2c Overexpression Lysate (Adult Normal) [NBL1-16833] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CP2c.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8267_CP2c%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16833-img0002.jpg)