TFCP2
| Gene Symbol | TFCP2 |
|---|---|
| Entrez Gene | 7024 |
| Alt Symbol | LBP1C, LSF, LSF1D, SEF, TFCP2C |
| Species | Human |
| Gene Type | protein-coding |
| Description | transcription factor CP2 |
| Other Description | SAA3 enhancer factor|alpha-globin transcription factor CP2 |
| Swissprots | Q12800 A8K5E9 Q9UD77 Q12801 Q9UD75 |
| Accessions | AAB29976 EAW58174 EAW58175 EAW58176 EAW58177 EAW58178 Q12800 AK291264 BAF83953 AK308087 AU133131 BC003634 AAH03634 BX479302 M84810 U03494 AAA21324 U03495 AAA21325 NM_001173452 NP_001166923 NM_001173453 NP_001166924 NM_005653 NP_005644 |
| Function | Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:7828600, ECO:0000269|PubMed:8114710}. |
| Tissue Specificity | Ubiquitous. Expressed in brain, ovary, kidney, thymus, spleen, liver, adrenal, heart and lung (at protein level). {ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:7828600, ECO:0000269|PubMed:8157699}. |
LBP-1C CRISPR/Cas9 KO Plasmid (h) - sc-418534 from Santa Cruz Biotechnology
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LBP-1C HDR Plasmid (h) - sc-418534-HDR from Santa Cruz Biotechnology
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LBP-1C Double Nickase Plasmid (h) - sc-418534-NIC from Santa Cruz Biotechnology
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LBP-1C Double Nickase Plasmid (h2) - sc-418534-NIC-2 from Santa Cruz Biotechnology
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LBP-1C CRISPR Activation Plasmid (h) - sc-418534-ACT from Santa Cruz Biotechnology
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LBP-1C CRISPR Activation Plasmid (h2) - sc-418534-ACT-2 from Santa Cruz Biotechnology
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LBP-1C Lentiviral Activation Particles (h) - sc-418534-LAC from Santa Cruz Biotechnology
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LBP-1C Lentiviral Activation Particles (h2) - sc-418534-LAC-2 from Santa Cruz Biotechnology
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LBP-1C siRNA (h) - sc-96237 from Santa Cruz Biotechnology
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LBP-1C shRNA Plasmid (h) - sc-96237-SH from Santa Cruz Biotechnology
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LBP-1C shRNA (h) Lentiviral Particles - sc-96237-V from Santa Cruz Biotechnology
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TFCP2 RNAi - H00007024-R01 from Novus Biologicals
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MISSION® esiRNA - EHU067301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21252 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21252 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03270 from Sigma-Aldrich
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TFCP2 siRNA (Human) - CRH4799 from Cohesion Biosciences
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TFCP2 - MBS8233711 from MyBioSource
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shRNA set against Human TFCP2 (NM_005653.4) - SHH426152 from Creative biogene
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shRNA set against Human TFCP2(NM_001173452.1) - SHL066762 from Creative biogene
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shRNA set against Human TFCP2(NM_001173453.1) - SHL066828 from Creative biogene
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TFCP2 shRNA Plasmid (Human) - CHH4799 from Cohesion Biosciences
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TFCP2 miRNA 3'UTR clone - MiUTR1H-10339 from Creative biogene
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TFCP2 miRNA 3'UTR clone - MiUTR1H-10340 from Creative biogene
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TFCP2 miRNA 3'UTR clone - MiUTR3H-02237 from Creative biogene
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