| Gene Symbol | KDM5C |
|---|---|
| Entrez Gene | 8242 |
| Alt Symbol | DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysine (K)-specific demethylase 5C |
| Other Description | JmjC domain-containing protein SMCX|Jumonji, AT rich interactive domain 1C (RBP2-like)|Jumonji/ARID domain-containing protein 1C|Smcx homolog, X chromosome|Smcy homolog, X-linked|histone demethylase JARID1C|lysine-specific demethylase 5C |
| Swissprots | B4E3I2 P41229 F5H3T1 Q7Z5S5 Q5JUX3 Q5JUX4 B0QZ44 Q5JUX5 |
| Accessions | CCQ43251 EAW93145 EAW93146 P41229 AI221739 AK304732 BAG65494 AK308077 BC047751 BC054499 AAH54499 BI711169 DB229140 EF613277 ABR13544 EU446742 ABZ92271 EU832126 ACE87476 EU832220 ACE86790 L25270 AAA61302 Z29650 CAA82758 XM_005262035 XP_005262092 XM_006724609 XP_006724672 XM_011530824 XP_011529126 XM_011530825 XP_011529127 XM_011530826 XP_011529128 XM_011530827 XP_011529129 XM_011530828 XP_011529130 XM_011530829 XP_011529131 XM_011530830 XP_011529132 XM_011530831 XP_011529133 XR_938369 XR_938370 XR_938371 XR_938372 XR_938373 NM_001146702 NP_001140174 NM_001282622 NP_001269551 NM_004187 NP_004178 |
| Function | Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}. |
| Tissue Specificity | Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. {ECO:0000269|PubMed:15586325}. |
Lysine-specific demethylase 5C (KDM5C), Human, ELISA Kit - E01L0319 from ARP American Research Products
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Lysine specific demethylase 5C (KDM5C), ELISA Kit - MBS7227888 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7239950 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7217203 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7207732 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7204185 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7229289 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7230587 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7225744 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7216020 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7242957 from MyBioSource
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Lysine-specific demethylase 5C (KDM5C), ELISA Kit - MBS7211001 from MyBioSource
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Human KDM5C ELISA Kit - E023203 from Biobool
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anti-KDM5C / Jarid1C / SMCX antibody - ARG53982 from Arigo Biolaboratories
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