KDM5C

Gene Symbol KDM5C
Entrez Gene 8242
Alt Symbol DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 5C
Other Description JmjC domain-containing protein SMCX|Jumonji, AT rich interactive domain 1C (RBP2-like)|Jumonji/ARID domain-containing protein 1C|Smcx homolog, X chromosome|Smcy homolog, X-linked|histone demethylase JARID1C|lysine-specific demethylase 5C
Swissprots B4E3I2 P41229 F5H3T1 Q7Z5S5 Q5JUX3 Q5JUX4 B0QZ44 Q5JUX5
Accessions CCQ43251 EAW93145 EAW93146 P41229 AI221739 AK304732 BAG65494 AK308077 BC047751 BC054499 AAH54499 BI711169 DB229140 EF613277 ABR13544 EU446742 ABZ92271 EU832126 ACE87476 EU832220 ACE86790 L25270 AAA61302 Z29650 CAA82758 XM_005262035 XP_005262092 XM_006724609 XP_006724672 XM_011530824 XP_011529126 XM_011530825 XP_011529127 XM_011530826 XP_011529128 XM_011530827 XP_011529129 XM_011530828 XP_011529130 XM_011530829 XP_011529131 XM_011530830 XP_011529132 XM_011530831 XP_011529133 XR_938369 XR_938370 XR_938371 XR_938372 XR_938373 NM_001146702 NP_001140174 NM_001282622 NP_001269551 NM_004187 NP_004178
Function Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}.
Tissue Specificity Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. {ECO:0000269|PubMed:15586325}.

JARID1C (D29B9) Rabbit mAb - 5361 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D29B9
Western blot analysis of extracts from NCCIT and F9 cell lines using JARID1C (D29B9) Rabbit mAb.

SmcX (G-10) - sc-376255 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SmcX (G-10): sc-376255. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

SmcX (F-12) - sc-373935 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SmcX (F-12): sc-373935. Western blot analysis of SmcX expression in non-transfected: sc-117752 (A) and human SmcX transfected: sc-177954 (B) 293T whole cell lysates.

SmcX (C-12) - sc-365861 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SmcX (C-12): sc-365861. Western blot analysis of SmcX expression in non-transfected: sc-117752 (A) and human SmcX transfected: sc-116240 (B) 293T whole cell lysates.

SmcX (C-1) - sc-365860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SmcX (C-1): sc-365860. Western blot analysis of SmcX expression in non-transfected: sc-117752 (A) and human SmcX transfected: sc-116240 (B) 293T whole cell lysates.

SmcX (H-99) - sc-98701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SmcX (H-99): sc-98701. Western blot analysis of SmcX expression in non-transfected: sc-117752 (A) and human SmcX transfected: sc-116240 (B) 293T whole cell lysates.

SmcX (D-14) - sc-83173 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SmcX (D-14): sc-83173. Western blot analysis of SmcX expression in non-transfected: sc-117752 (A) and human SmcX transfected: sc-177954 (B) 293T whole cell lysates.

Anti-KDM5C / Jarid1C / SMCX antibody - ab190180 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KDM5C / Jarid1C / SMCX antibody (ab190180) at 1/2000 dilutionLane 1 : Human U2OS cell lysateLane 2 : Human U2OS cells transfected with KDM5C / Jarid1C / SMCX siRNALane 3 : Mouse embryo fibroblasts (MEFs)Lane 4 : Rat INS1 cell lysateLane 5 : Chicken DT40 cell lysateLysates/proteins at 30 µg per lane.

Anti-KDM5C / Jarid1C / SMCX antibody [2E4-E1-G8] - ab106068 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E4-E1-G8
Immunofluorescence image of HeLa cells using an anti-KDM5C antibody (ab106068) at a dilution of 1:150.

Anti-KDM5C / Jarid1C / SMCX antibody - ChIP Grade - ab34718 from Abcam

Prices $392.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-KDM5C / Jarid1C / SMCX antibody - ChIP Grade (ab34718) at 1/250 dilution + HEK293 (Human embryonic kidney cell line) Whole Cell Lysate (ab7902) at 20 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal - ab190181 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KDM5C / Jarid1C / SMCX antibody - N-terminal (ab190181) at 1/2000 dilutionLane 1 : Human U2OS cell lysateLane 2 : Human U2OS cell lysate transfected with KDM5C / Jarid1C / SMCX siRNALane 3 : Mouse embryo fibroblasts (MEFs) cell lysateLane 4 : Rat INS1 cell lysateLane 5 : Chicken DT40 cell lysateLysates/proteins at 30 µg per lane.

Anti-KDM5C / Jarid1C / SMCX Antibody (C-Terminus) IHC-plus™ - LS-B9465 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Anti-KDM5C / Jarid1C / SMCX antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-KDM5C / Jarid1C / SMCX Antibody (aa275-325) - LS-C71159 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-KDM5C / Jarid1C / SMCX Antibody (C-Terminus) - LS-C71158 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-KDM5C / Jarid1C / SMCX Antibody (aa275-325) - LS-C287868 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5C / Jarid1C / SMCX Antibody (C-Terminus) - LS-C287865 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5C / Jarid1C / SMCX Antibody - LS-C347728 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-KDM5C / Jarid1C / SMCX Antibody - LS-C109434 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: A431. B: Hela. 5% SDS PAGE. JARID1C antibody diluted at 1:1000.

Anti-KDM5C / Jarid1C / SMCX Antibody - LS-C335219 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HeLa cell lines, using KDM5C antibody.

SMCX Antibody - NB100-55328 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMCX Antibody - 22270002 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ELISA: SMCX Antibody [22270002] - Affinity Purified

SMCX Antibody - NB100-55327 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMCX Antibody [NB100-55327] - Detection of Human JARID1C on HeLa whole cell lysate using NB100-55327. JARID1C was also immunoprecipitated by rabbit anti-JARID1C antibody NB100-55328.

SMCX Antibody - NBP2-20422 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMCX Antibody [NBP2-20422] - Sample (30 ug of whole cell lysate) A: IMR32 5% SDS PAGE gel, diluted at 1:10000.

Anti-KDM5C (N-terminal) antibody produced in rabbit - SAB2700072 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KDM5C (N-terminal): <B>Cat. No. SAB2700072</B>: Western Blot analysis of KDM5C in extracts from <B>Lanes</B><BR/>A. A431 <BR/>B. HeLa using <B>Cat. No. SAB2700072</B> at a 1:1000 dilution.

Anti-KDM5C (N-terminal) antibody produced in rabbit - SAB2700073 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KDM5C (N-terminal): <B>Cat. No. SAB2700073</B>: Western Blot analysis of KDM5C in extracts from <B>Lanes</B><BR/>A. IMR32 using <B>Cat. No. SAB2700073</B> at a 1:10000 dilution.
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