| Gene Symbol |
KDM5C
|
| Entrez Gene |
8242
|
| Alt Symbol |
DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 5C
|
| Other Description |
JmjC domain-containing protein SMCX|Jumonji, AT rich interactive domain 1C (RBP2-like)|Jumonji/ARID domain-containing protein 1C|Smcx homolog, X chromosome|Smcy homolog, X-linked|histone demethylase JARID1C|lysine-specific demethylase 5C
|
| Swissprots |
B4E3I2 P41229 F5H3T1 Q7Z5S5 Q5JUX3 Q5JUX4 B0QZ44 Q5JUX5
|
| Accessions |
CCQ43251 EAW93145 EAW93146 P41229 AI221739 AK304732 BAG65494 AK308077 BC047751 BC054499 AAH54499 BI711169 DB229140 EF613277 ABR13544 EU446742 ABZ92271 EU832126 ACE87476 EU832220 ACE86790 L25270 AAA61302 Z29650 CAA82758 XM_005262035 XP_005262092 XM_006724609 XP_006724672 XM_011530824 XP_011529126 XM_011530825 XP_011529127 XM_011530826 XP_011529128 XM_011530827 XP_011529129 XM_011530828 XP_011529130 XM_011530829 XP_011529131 XM_011530830 XP_011529132 XM_011530831 XP_011529133 XR_938369 XR_938370 XR_938371 XR_938372 XR_938373 NM_001146702 NP_001140174 NM_001282622 NP_001269551 NM_004187 NP_004178
|
| Function |
Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}.
|
| Tissue Specificity |
Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. {ECO:0000269|PubMed:15586325}.
|