KDM5C

Gene Symbol KDM5C
Entrez Gene 8242
Alt Symbol DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 5C
Other Description JmjC domain-containing protein SMCX|Jumonji, AT rich interactive domain 1C (RBP2-like)|Jumonji/ARID domain-containing protein 1C|Smcx homolog, X chromosome|Smcy homolog, X-linked|histone demethylase JARID1C|lysine-specific demethylase 5C
Swissprots B4E3I2 P41229 F5H3T1 Q7Z5S5 Q5JUX3 Q5JUX4 B0QZ44 Q5JUX5
Accessions CCQ43251 EAW93145 EAW93146 P41229 AI221739 AK304732 BAG65494 AK308077 BC047751 BC054499 AAH54499 BI711169 DB229140 EF613277 ABR13544 EU446742 ABZ92271 EU832126 ACE87476 EU832220 ACE86790 L25270 AAA61302 Z29650 CAA82758 XM_005262035 XP_005262092 XM_006724609 XP_006724672 XM_011530824 XP_011529126 XM_011530825 XP_011529127 XM_011530826 XP_011529128 XM_011530827 XP_011529129 XM_011530828 XP_011529130 XM_011530829 XP_011529131 XM_011530830 XP_011529132 XM_011530831 XP_011529133 XR_938369 XR_938370 XR_938371 XR_938372 XR_938373 NM_001146702 NP_001140174 NM_001282622 NP_001269551 NM_004187 NP_004178
Function Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}.
Tissue Specificity Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. {ECO:0000269|PubMed:15586325}.

SmcX CRISPR/Cas9 KO Plasmid (h) - sc-405760 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX HDR Plasmid (h) - sc-405760-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX Double Nickase Plasmid (h) - sc-405760-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX Double Nickase Plasmid (h2) - sc-405760-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX CRISPR Activation Plasmid (h) - sc-405760-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX CRISPR Activation Plasmid (h2) - sc-405760-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX Lentiviral Activation Particles (h) - sc-405760-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX Lentiviral Activation Particles (h2) - sc-405760-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SmcX siRNA (h) - sc-76519 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SmcX shRNA Plasmid (h) - sc-76519-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SmcX shRNA (h) Lentiviral Particles - sc-76519-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMCX RNAi - H00008242-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU005071 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11036 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11036 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KDM5C siRNA (Human) - CRH5412 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KDM5C (NM_004187.3) - SHH324255 from Creative biogene

Category siRNA
Species Reactivities Human

KDM5C shRNA Plasmid (Human) - CHH5412 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KDM5C miRNA 3'UTR clone - MiUTR3H-03034 from Creative biogene

Species Reactivities Human

KDM5C miRNA 3'UTR clone - MiUTR3H-03035 from Creative biogene

Species Reactivities Human
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