KDM5C

Gene Symbol	KDM5C
Entrez Gene	8242
Alt Symbol	DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific demethylase 5C
Other Description	JmjC domain-containing protein SMCX|Jumonji, AT rich interactive domain 1C (RBP2-like)|Jumonji/ARID domain-containing protein 1C|Smcx homolog, X chromosome|Smcy homolog, X-linked|histone demethylase JARID1C|lysine-specific demethylase 5C
Swissprots	B4E3I2 P41229 F5H3T1 Q7Z5S5 Q5JUX3 Q5JUX4 B0QZ44 Q5JUX5
Accessions	CCQ43251 EAW93145 EAW93146 P41229 AI221739 AK304732 BAG65494 AK308077 BC047751 BC054499 AAH54499 BI711169 DB229140 EF613277 ABR13544 EU446742 ABZ92271 EU832126 ACE87476 EU832220 ACE86790 L25270 AAA61302 Z29650 CAA82758 XM_005262035 XP_005262092 XM_006724609 XP_006724672 XM_011530824 XP_011529126 XM_011530825 XP_011529127 XM_011530826 XP_011529128 XM_011530827 XP_011529129 XM_011530828 XP_011529130 XM_011530829 XP_011529131 XM_011530830 XP_011529132 XM_011530831 XP_011529133 XR_938369 XR_938370 XR_938371 XR_938372 XR_938373 NM_001146702 NP_001140174 NM_001282622 NP_001269551 NM_004187 NP_004178
Function	Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250|UniProtKB:P41230, ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17468742}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}.
Tissue Specificity	Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. {ECO:0000269|PubMed:15586325}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human KDM5C / Jarid1C / SMCX full length protein - ab196392 from Abcam Category Protein Prices $1,281.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human KDM5C / Jarid1C / SMCX peptide - ab35501 from Abcam Category Peptide

Human KDM5C / Jarid1C / SMCX protein fragment - ab125608 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

KDM5C fusion protein - Ag15079 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

KDM5C fusion protein - Ag5791 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SMCX (963-973) (human) - 89130 from NeoScientific Category Peptide Prices $90.00, $150.00, $300.00 Sizes 5 mg, 10 mg, 25 mg Species Human

Recombinant JARID1C / KDM5C protein - 31433 from ActiveMotif Category Protein Prices $395.00, $3,800.00 Sizes 20 μg, 1 mg Source Baculovirus Species Human

Recombinant Human Lysine (K)-Specific Demethylase 5C, GST-tagged - KDM5C-1604H from Creative Biomart Category Protein Species Human

Recombinant Human KDM5C, GST-tagged - KDM5C-7032H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human KDM5C, FLAG-tagged - KDM5C-45H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

KDM5C protein-GST fusion - 009-001-S37 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

KDM5C protein-GST fusion - 009-001-S37S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Lysine-specific demethylase 5C(KDM5C) ,partial - CSB-YP011939HU CSB-EP011939HU CSB-BP011939HU CSB-MP011939HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SMCX (963-973) - abx265113 from Abbexa Source Human Species Human

SMCX (963-973) (human) - H08001 from Creative Peptides Category Peptide Species Human

KDM5C Peptide, Human - M34GP08052H from Creative Peptides Category Peptide Source Synthetic. Species Human

SMCX (963-973) (Human) - CCP2894 from Cohesion Biosciences Category Peptide Prices $125.00, $313.00, $469.00 Sizes 1 mg, 5 mg, 10 mg Species Human

SMCX Recombinant Protein Antigen - NBP2-55009PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SMCX Recombinant Protein Antigen - NBP2-55541PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

KDM5C, Recombinant Protein - MBS515203 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

Lysine-specific demethylase 5C (KDM5C), partial, Recombinant Protein - MBS963000 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SMCX (963-973) - orb372827 from Biorbyt Category Peptide Species Human

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