MGRN1

Gene Symbol	MGRN1
Entrez Gene	23295
Alt Symbol	RNF156
Species	Human
Gene Type	protein-coding
Description	mahogunin ring finger 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MGRN1\|RING finger protein 156\|mahogunin RING finger protein 1\|mahogunin, ring finger 1\|probable E3 ubiquitin-protein ligase MGRN1
Swissprots	Q86W76 A4URL3 A4URL4 O60291
Accessions	EAW85279 EAW85280 EAW85281 EAW85282 O60291 AB011116 BAA25470 AK299052 BAG61124 BC007627 BC014199 BC050389 AAH50389 CN314787 DA118421 DA590130 EF471397 ABO69623 EF471398 ABO69624 XM_005255217 XP_005255274 XM_005255218 XP_005255275 XM_005255219 XP_005255276 XM_005255220 XP_005255277 XM_005255221 XP_005255278 XM_011522441 XP_011520743 XM_011522442 XP_011520744 XR_429639 NM_001142289 NP_001135761 NM_001142290 NP_001135762 NM_001142291 NP_001135763 NM_015246 NP_056061 NR_102267
Function	E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269\|PubMed:17229889, ECO:0000269\|PubMed:19703557, ECO:0000269\|PubMed:19737927}.
Subcellular Location	Isoform 4: Cytoplasm, cytosol. Cell membrane.
Top Pathways	Ubiquitin mediated proteolysis

MGRN1 (E-15) - sc-160518 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MGRN1 (E-15): sc-160518. Western blot analysis of MGRN1 expression in Ca Ski whole cell lysate.

MGRN1 (N-16) - sc-160519 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MGRN1 (LM-1A33) - sc-134385 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

MGRN1 (LM-1A33): sc-134385. Western blot analysis of MGRN1 expression in human MGRN1 transfected (A) and non-transfected (B) 293T whole cell lysates.

MGRN1 (P-14) - sc-160520 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-RNF156 antibody - ab85235 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RNF156 antibody (ab85235) at 1/50 dilution + T47D cell line lysate at 35 µg

Anti-RNF156 antibody - ab57406 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab57406 RNF156 antibody at 1ug/ml.

Anti-RNF156 antibody - ab101997 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Lane 1: An antibody to RNF156 at 0.4 µg/ml staining RNF156 in HeLa cell lysate immunoprecipitated using ab101997 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Lane 2: Control IgG Detection: Chemiluminescence with an exposure time of 10 seconds

Anti-RNF156 antibody [3C3] - ab124039 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3C3

All lanes : Anti-RNF156 antibody [3C3] (ab124039) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY RNF156 cDNALysates/proteins at 5 µg per lane.

Anti-MGRN1 Antibody (aa400-450) - LS-C289620 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MGRN1 Antibody - LS-C310972 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-MGRN1 Antibody (aa477-577) - LS-C309216 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-MGRN1 Antibody (aa505-555) - LS-C289621 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-MGRN1 Antibody (aa252-301) - LS-C80553 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-MGRN1 Antibody (clone 3C3) - LS-C172847 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3C3

Anti-MGRN1 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MGRN1.

Anti-MGRN1 Antibody (clone 1E12) - LS-C337320 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1E12

Anti-MGRN1 Antibody (clone 1A8) - LS-C337321 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1A8

Anti-MGRN1 Antibody (clone 2A7) - LS-C337322 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2A7

Anti-MGRN1 Antibody (clone 1A11) - LS-C172844 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1A11

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MGRN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MGRN1.

Anti-MGRN1 Antibody (clone 3A6) - LS-C172839 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3A6

Anti-MGRN1 Antibody (clone 3A1) - LS-C172845 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3A1

MGRN1 Antibody (3C3) - NBP2-00586 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3C3

Western Blot: MGRN1 Antibody (3C3) [NBP2-00586] Analysis of extracts (35ug) from 9 different cell lines by using anti-MGRN1 monoclonal antibody.

MGRN1 Antibody - H00023295-D01P from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: MGRN1 Antibody [H00023295-D01P] - Analysis of MGRN1 expression in mouse spleen.

MGRN1 Antibody (3E1) - H00023295-M07 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3E1

MGRN1 Antibody - NBP1-49929 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: MGRN1 Antibody [NBP1-49929] - Detection of Human MGRN1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-MGRN1 antibody used for WB at 0.04 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 3 mcg/mg lysate. MGRN1 was also immunoprecipitated by rabbit anti-MGRN1 antibody which recognizes a downstream epitope. For blotting immunoprecipitated MGRN1 was used. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).

MGRN1 Antibody - NBP2-17286 from Novus Biologicals

Prices	$349.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: MGRN1 Antibody [NBP2-17286] - Sample (30 ug of whole cell lysate) A: IMR32 7. 5% SDS PAGE gel, diluted at 1:1000.

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