MGRN1

Gene Symbol MGRN1
Entrez Gene 23295
Alt Symbol RNF156
Species Human
Gene Type protein-coding
Description mahogunin ring finger 1, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase MGRN1|RING finger protein 156|mahogunin RING finger protein 1|mahogunin, ring finger 1|probable E3 ubiquitin-protein ligase MGRN1
Swissprots Q86W76 A4URL3 A4URL4 O60291
Accessions EAW85279 EAW85280 EAW85281 EAW85282 O60291 AB011116 BAA25470 AK299052 BAG61124 BC007627 BC014199 BC050389 AAH50389 CN314787 DA118421 DA590130 EF471397 ABO69623 EF471398 ABO69624 XM_005255217 XP_005255274 XM_005255218 XP_005255275 XM_005255219 XP_005255276 XM_005255220 XP_005255277 XM_005255221 XP_005255278 XM_011522441 XP_011520743 XM_011522442 XP_011520744 XR_429639 NM_001142289 NP_001135761 NM_001142290 NP_001135762 NM_001142291 NP_001135763 NM_015246 NP_056061 NR_102267
Function E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
Subcellular Location Isoform 4: Cytoplasm, cytosol. Cell membrane.
Top Pathways Ubiquitin mediated proteolysis

MGRN1 CRISPR/Cas9 KO Plasmid (h) - sc-405334 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 HDR Plasmid (h) - sc-405334-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 Double Nickase Plasmid (h) - sc-405334-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 Double Nickase Plasmid (h2) - sc-405334-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 CRISPR Activation Plasmid (h) - sc-405334-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 CRISPR Activation Plasmid (h2) - sc-405334-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 Lentiviral Activation Particles (h) - sc-405334-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 Lentiviral Activation Particles (h2) - sc-405334-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MGRN1 siRNA (h) - sc-92983 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MGRN1 shRNA Plasmid (h) - sc-92983-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MGRN1 shRNA (h) Lentiviral Particles - sc-92983-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU138301 from Sigma-Aldrich

Category siRNA

MISSION® esiRNA - EHU020181 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13305 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13305 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MGRN1 siRNA (Human) - CRH8158 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MGRN1 RNAi - H00023295-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MGRN1 (NM_015246.3) - SHH341707 from Creative biogene

Category siRNA
Species Reactivities Human

Human MGRN1 siRNA - orb268660 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MGRN1 shRNA Plasmid (Human) - CHH8158 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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