MGRN1

Gene Symbol	MGRN1
Entrez Gene	23295
Alt Symbol	RNF156
Species	Human
Gene Type	protein-coding
Description	mahogunin ring finger 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MGRN1|RING finger protein 156|mahogunin RING finger protein 1|mahogunin, ring finger 1|probable E3 ubiquitin-protein ligase MGRN1
Swissprots	Q86W76 A4URL3 A4URL4 O60291
Accessions	EAW85279 EAW85280 EAW85281 EAW85282 O60291 AB011116 BAA25470 AK299052 BAG61124 BC007627 BC014199 BC050389 AAH50389 CN314787 DA118421 DA590130 EF471397 ABO69623 EF471398 ABO69624 XM_005255217 XP_005255274 XM_005255218 XP_005255275 XM_005255219 XP_005255276 XM_005255220 XP_005255277 XM_005255221 XP_005255278 XM_011522441 XP_011520743 XM_011522442 XP_011520744 XR_429639 NM_001142289 NP_001135761 NM_001142290 NP_001135762 NM_001142291 NP_001135763 NM_015246 NP_056061 NR_102267
Function	E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
Subcellular Location	Isoform 4: Cytoplasm, cytosol. Cell membrane.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MGRN1 Gene cDNA Clone - orb144249 from Biorbyt Prices $366.00 Sizes 10 μg Species Human

MGRN1 - MBS1265818 from MyBioSource Species Human Accession BC050389

Human MGRN1 Gene ORF cDNA clone in cloning vector - HG15227-G from Sino Biological Species Human

Mouse MGRN1 ORF clone (NM_001142289.2) - CDCL132527 from Creative biogene Species Human

Mouse MGRN1 ORF clone (NM_001142291.2) - CDCL132529 from Creative biogene Species Human

Human MGRN1 ORF Clone (BC050389) - CDCS408242 from Creative biogene Species Human Accession O60291

Human MGRN1 ORF clone (BC050389) - CDCB158305 from Creative biogene Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid - HG15227-UT from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15227-NY from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15227-CY from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, C-His tag - HG15227-CH from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15227-NF from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15227-CF from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15227-ANG from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15227-NM from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15227-ACR from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15227-ACG from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15227-ANR from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15227-CM from Sino Biological Species Human

Human MGRN1 Gene ORF cDNA clone expression plasmid, N-His tag - HG15227-NH from Sino Biological Species Human

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