MGRN1

Gene Symbol	MGRN1
Entrez Gene	23295
Alt Symbol	RNF156
Species	Human
Gene Type	protein-coding
Description	mahogunin ring finger 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MGRN1|RING finger protein 156|mahogunin RING finger protein 1|mahogunin, ring finger 1|probable E3 ubiquitin-protein ligase MGRN1
Swissprots	Q86W76 A4URL3 A4URL4 O60291
Accessions	EAW85279 EAW85280 EAW85281 EAW85282 O60291 AB011116 BAA25470 AK299052 BAG61124 BC007627 BC014199 BC050389 AAH50389 CN314787 DA118421 DA590130 EF471397 ABO69623 EF471398 ABO69624 XM_005255217 XP_005255274 XM_005255218 XP_005255275 XM_005255219 XP_005255276 XM_005255220 XP_005255277 XM_005255221 XP_005255278 XM_011522441 XP_011520743 XM_011522442 XP_011520744 XR_429639 NM_001142289 NP_001135761 NM_001142290 NP_001135762 NM_001142291 NP_001135763 NM_015246 NP_056061 NR_102267
Function	E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
Subcellular Location	Isoform 4: Cytoplasm, cytosol. Cell membrane.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MGRN1 293T Cell Transient Overexpression Lysate(Denatured) - H00023295-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MGRN1 overexpression lysate - LY414714 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MGRN1 overexpression lysate - LY428013 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MGRN1 overexpression lysate - LY428014 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MGRN1 293 Cell Lysate - 407025 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

MGRN1 Overexpression Lysate (Denatured) - H00023295-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

MGRN1 Overexpression Lysate (Native) - NBL1-13092 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MGRN1 (h): 293T Lysate - sc-116092 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

MGRN1 Over-expression Lysate Product - GWB-6BA89B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human MGRN1 Knockdown Stable Cell Line - CSC-DC009495 from Creative biogene Category Cell Line Species Human

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