MGRN1

Gene Symbol	MGRN1
Entrez Gene	23295
Alt Symbol	RNF156
Species	Human
Gene Type	protein-coding
Description	mahogunin ring finger 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase MGRN1|RING finger protein 156|mahogunin RING finger protein 1|mahogunin, ring finger 1|probable E3 ubiquitin-protein ligase MGRN1
Swissprots	Q86W76 A4URL3 A4URL4 O60291
Accessions	EAW85279 EAW85280 EAW85281 EAW85282 O60291 AB011116 BAA25470 AK299052 BAG61124 BC007627 BC014199 BC050389 AAH50389 CN314787 DA118421 DA590130 EF471397 ABO69623 EF471398 ABO69624 XM_005255217 XP_005255274 XM_005255218 XP_005255275 XM_005255219 XP_005255276 XM_005255220 XP_005255277 XM_005255221 XP_005255278 XM_011522441 XP_011520743 XM_011522442 XP_011520744 XR_429639 NM_001142289 NP_001135761 NM_001142290 NP_001135762 NM_001142291 NP_001135763 NM_015246 NP_056061 NR_102267
Function	E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. {ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557, ECO:0000269|PubMed:19737927}.
Subcellular Location	Isoform 4: Cytoplasm, cytosol. Cell membrane.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF156 full length protein - ab161592 from Abcam Category Protein Source Wheat germ Species Human

Human RNF156 full length protein - ab167954 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human RNF156 protein fragment - ab161593 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human MGRN1 Protein - H00023295-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MGRN1 Protein - H00023295-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MGRN1-Antibody-C-term-Blocking-Peptide - BP7634b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MGRN1-Antibody-N-term-Blocking-Peptide - BP7634a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MGRN1 Blocking Peptide - 33R-2492 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MGRN1 / RNF156 - H00023295-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MGRN1 / RNF156 - H00023295-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MGRN1 / RNF156 - H00023295-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MGRN1 / RNF156 - H00023295-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MGRN1 fusion protein - ag1808 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MGRN1, GST-tagged - MGRN1-179H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

MGRN1 protein-GST fusion - 009-001-S48 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

MGRN1 protein-GST fusion - 009-001-S48S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human E3 ubiquitin-protein ligase MGRN1(MGRN1) - CSB-YP013790HU CSB-EP013790HU CSB-BP013790HU CSB-MP013790HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MGRN1 / RNF156 (transcript variant 1) - TP308284 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MGRN1 Recombinant Protein Antigen - NBP1-82998PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MGRN1 Peptide, Human - M34GP09495H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase MGRN1 (MGRN1), Recombinant Protein - MBS1038117 from MyBioSource Category Protein Prices $1,345.00, $1,345.00, $1,565.00, $1,565.00, $2,230.00, $2,230.00, $2,695.00, $2,695.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MGRN1, Recombinant Protein - MBS515305 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

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