| Gene Symbol |
DOK3
|
| Entrez Gene |
79930
|
| Alt Symbol |
DOKL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
docking protein 3
|
| Other Description |
Dok-like protein|downstream of tyrosine kinase 3
|
| Swissprots |
Q9H666 Q8N864 H7BXS0 Q7L591 Q9BQB3 E9PAT0
|
| Accessions |
EAW84982 EAW84983 EAW84984 Q7L591 AK026223 BAB15399 AK097258 BAC04986 AK307300 AL583057 AL833678 BC004564 AAH04564 BC004867 AAH04867 BG756981 BI489608 CF138017 DA674730 DA931137 XM_005265984 XP_005266041 XM_005265985 XP_005266042 XM_005265987 XP_005266044 XM_011534654 XP_011532956 XM_011534655 XP_011532957 XM_011534656 XP_011532958 XM_011534657 XP_011532959 NM_001144875 NP_001138347 NM_001144876 NP_001138348 NM_001308235 NP_001295164 NM_001308236 NP_001295165 NM_024872 NP_079148
|
| Function |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
|
| Tissue Specificity |
Expressed in spleen. {ECO:0000269|PubMed:12595900}.
|
