FBXO9

Gene Symbol FBXO9
Entrez Gene 26268
Alt Symbol FBX9, NY-REN-57, VCIA1, dJ341E18.2
Species Human
Gene Type protein-coding
Description F-box protein 9
Other Description F-box only protein 9|F-box protein Fbx9|cross-immune reaction antigen 1|renal carcinoma antigen NY-REN-57
Swissprots B3KMM6 Q59EH8 Q9Y593 O75986 Q9UK97 A6NFW3 Q9NT57 Q6PKH7
Accessions EAX04405 EAX04406 EAX04407 EAX04408 EAX04409 EAX04410 Q9UK97 AA132361 AA890006 AB209833 BAD93070 AF174597 AAF04518 AF176704 AAF03704 AK021559 BAG51038 AK095307 AK095315 AL137520 CAB70786 AY858798 AAW51115 BC000650 AAH00650 BC024973 BX641082 XM_005248995 XP_005249052 XM_005248996 XP_005249053 XM_011514464 XP_011512766 NM_012347 NP_036479 NM_033480 NP_258441 NM_033481 NP_258442
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. {ECO:0000269|PubMed:23263282}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23263282}.

FBXO9 (C-14) - sc-242808 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FBX09 antibody - ab118381 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ab118381, at 3 ug/ml, staining FBXO9 in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry.

Anti-FBX09 antibody - C-terminal - ab174917 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FBX09 antibody - C-terminal (ab174917) at 1/100 dilution + Mouse liver tissue lysate at 15 µg

Anti-FBX09 / FBXO9 Antibody (aa179-228) IHC-plus™ - LS-B11926 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-FBX09 / FBXO9 Antibody (aa8-25) - LS-C149028 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa1-50) - LS-C148734 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa346-373, APC) - LS-C235249 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa346-373, AP) - LS-C235248 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa346-373, Biotin) - LS-C235250 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (clone 1G12) - LS-C134057 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G12
Detection limit for recombinant GST tagged FBXO9 is 1 ng/ml as a capture antibody.

Anti-FBX09 / FBXO9 Antibody (aa346-373, FITC) - LS-C235251 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa346-373, PE) - LS-C235253 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa346-373, Azide-free, HRP) - LS-C249978 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa353-382) - LS-C321328 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody - LS-C307988 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-FBX09 / FBXO9 Antibody (aa346-373) - LS-C166091 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FBXO9 Antibody western blot of mouse liver tissue lysates (15 ug/lane). The FBXO9 antibody detected FBXO9 protein (arrow).

Anti-FBX09 / FBXO9 Antibody (aa431-447) IHC-plus™ - LS-B371 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FBXO9 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B371 concentration 5 ug/ml.

FBX09 Antibody - NBP1-55054 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FBX09 Antibody [NBP1-55054] - NCI-H226 cell lysate, concentration 0.2-1 ug/ml.

FBX09 Antibody - NBP2-27364 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal

FBX09 Antibody - NBP1-02445 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: FBX09 Antibody [NBP1-02445] - Staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

FBX09 Antibody - H00026268-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: FBX09 Antibody [H00026268-B01] - analysis of FBXO9 expression in transfected 293T cell line by FBXO9 MaxPab polyclonal antibody (B01). Lane 1: FBXO9 transfected lysate (51.10 KDa). Lane 2: Non-transfected lysate.

FBX09 Antibody - NBP1-78064 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FBX09 Antibody [NBP1-78064] - Shows detection of a band at ~100 kDa (arrowhead) believed to correspond to FBOX9 present in a MCF7 whole cell lysate (lane 1). Specific band reactivity is greatly diminished when the antibody is pre-incubated with the immunizing peptide (data not shown). Approximately 35 ug of lysate was separated by 4-20% Tris Glycine SDS-PAGE. After blocking, the membrane was probed overnight at 4C with the primary antibody diluted to 1:1,500. The membrane was washed and reacted with a 1:10,000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L] for 45 min at room temperature (800 nm channel, green). Molecular weight estimation was made by comparison to prestained MW markers (indicated at left, 700 nm channel, red).

FBX09 Antibody (1G12) - H00026268-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G12

FBX09 Antibody - H00026268-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: FBX09 Antibody [H00026268-B01P] - Analysis of FBXO9 expression in transfected 293T cell line by FBXO9 polyclonal antibody. Lane 1: FBXO9 transfected lysate(48.07 KDa). Lane 2: Non-transfected lysate.

FBX09 Antibody - H00026268-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal
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