FBXO9
| Gene Symbol | FBXO9 |
|---|---|
| Entrez Gene | 26268 |
| Alt Symbol | FBX9, NY-REN-57, VCIA1, dJ341E18.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | F-box protein 9 |
| Other Description | F-box only protein 9|F-box protein Fbx9|cross-immune reaction antigen 1|renal carcinoma antigen NY-REN-57 |
| Swissprots | B3KMM6 Q59EH8 Q9Y593 O75986 Q9UK97 A6NFW3 Q9NT57 Q6PKH7 |
| Accessions | EAX04405 EAX04406 EAX04407 EAX04408 EAX04409 EAX04410 Q9UK97 AA132361 AA890006 AB209833 BAD93070 AF174597 AAF04518 AF176704 AAF03704 AK021559 BAG51038 AK095307 AK095315 AL137520 CAB70786 AY858798 AAW51115 BC000650 AAH00650 BC024973 BX641082 XM_005248995 XP_005249052 XM_005248996 XP_005249053 XM_011514464 XP_011512766 NM_012347 NP_036479 NM_033480 NP_258441 NM_033481 NP_258442 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. {ECO:0000269|PubMed:23263282}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23263282}. |
FBXO9 CRISPR/Cas9 KO Plasmid (h) - sc-409883 from Santa Cruz Biotechnology
|
||||||||
FBXO9 HDR Plasmid (h) - sc-409883-HDR from Santa Cruz Biotechnology
|
||||||||
FBXO9 Double Nickase Plasmid (h) - sc-409883-NIC from Santa Cruz Biotechnology
|
||||||||
FBXO9 Double Nickase Plasmid (h2) - sc-409883-NIC-2 from Santa Cruz Biotechnology
|
||||||||
FBXO9 CRISPR Activation Plasmid (h) - sc-409883-ACT from Santa Cruz Biotechnology
|
||||||||
FBXO9 CRISPR Activation Plasmid (h2) - sc-409883-ACT-2 from Santa Cruz Biotechnology
|
||||||||
FBXO9 Lentiviral Activation Particles (h) - sc-409883-LAC from Santa Cruz Biotechnology
|
||||||||
FBXO9 Lentiviral Activation Particles (h2) - sc-409883-LAC-2 from Santa Cruz Biotechnology
|
||||||||
FBXO9 siRNA (h) - sc-95076 from Santa Cruz Biotechnology
|
||||||||
FBXO9 shRNA Plasmid (h) - sc-95076-SH from Santa Cruz Biotechnology
|
||||||||
FBXO9 shRNA (h) Lentiviral Particles - sc-95076-V from Santa Cruz Biotechnology
|
||||||||
FBX09 RNAi - H00026268-R01 from Novus Biologicals
|
||||||||
FBX09 RNAi - H00026268-R03 from Novus Biologicals
|
||||||||
FBX09 RNAi - H00026268-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU085761 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN8569 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8569 from Sigma-Aldrich
|
||||||||
FBXO9 siRNA (Human) - CRH8791 from Cohesion Biosciences
|
||||||||
FBXO9 - MBS8228005 from MyBioSource
|
||||||||
shRNA set against Human FBXO9 (NM_012347.4) - SHH293441 from Creative biogene
|
||||||||
shRNA set against Human FBXO9(NM_033481.3) - SHH053291 from Creative biogene
|
||||||||
shRNA set against Human FBXO9(NM_012347.4) - SHH053353 from Creative biogene
|
||||||||
shRNA set against Human FBXO9(NM_033480.2) - SHH053371 from Creative biogene
|
||||||||
shRNA set against Human FBXO9(NM_033481.3) - SHH053389 from Creative biogene
|
||||||||
FBXO9 shRNA Plasmid (Human) - CHH8791 from Cohesion Biosciences
|