FBXO9

Gene Symbol	FBXO9
Entrez Gene	26268
Alt Symbol	FBX9, NY-REN-57, VCIA1, dJ341E18.2
Species	Human
Gene Type	protein-coding
Description	F-box protein 9
Other Description	F-box only protein 9|F-box protein Fbx9|cross-immune reaction antigen 1|renal carcinoma antigen NY-REN-57
Swissprots	B3KMM6 Q59EH8 Q9Y593 O75986 Q9UK97 A6NFW3 Q9NT57 Q6PKH7
Accessions	EAX04405 EAX04406 EAX04407 EAX04408 EAX04409 EAX04410 Q9UK97 AA132361 AA890006 AB209833 BAD93070 AF174597 AAF04518 AF176704 AAF03704 AK021559 BAG51038 AK095307 AK095315 AL137520 CAB70786 AY858798 AAW51115 BC000650 AAH00650 BC024973 BX641082 XM_005248995 XP_005249052 XM_005248996 XP_005249053 XM_011514464 XP_011512766 NM_012347 NP_036479 NM_033480 NP_258441 NM_033481 NP_258442
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. {ECO:0000269|PubMed:23263282}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:23263282}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FBXO9-Over-expression-Lysate - LY15394a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

FBXO9 293T Cell Transient Overexpression Lysate(Denatured) - H00026268-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

FBXO9 overexpression lysate - LY409521 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FBXO9 overexpression lysate - LY415805 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

FBXO9 overexpression lysate - LY429364 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

FBXO9 293 Cell Lysate - 404996 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

FBX09 Overexpression Lysate (Native) - NBL1-10643 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FBXO9 Over-expression Lysate Product - GWB-B1F9F4 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

FBX09 Overexpression Lysate (Denatured) - H00026268-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human FBXO9 Knockdown Stable Cell Line - CSC-DC005620 from Creative biogene Category Cell Line Species Human

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