FBXO9

Gene Symbol FBXO9
Entrez Gene 26268
Alt Symbol FBX9, NY-REN-57, VCIA1, dJ341E18.2
Species Human
Gene Type protein-coding
Description F-box protein 9
Other Description F-box only protein 9|F-box protein Fbx9|cross-immune reaction antigen 1|renal carcinoma antigen NY-REN-57
Swissprots B3KMM6 Q59EH8 Q9Y593 O75986 Q9UK97 A6NFW3 Q9NT57 Q6PKH7
Accessions EAX04405 EAX04406 EAX04407 EAX04408 EAX04409 EAX04410 Q9UK97 AA132361 AA890006 AB209833 BAD93070 AF174597 AAF04518 AF176704 AAF03704 AK021559 BAG51038 AK095307 AK095315 AL137520 CAB70786 AY858798 AAW51115 BC000650 AAH00650 BC024973 BX641082 XM_005248995 XP_005249052 XM_005248996 XP_005249053 XM_011514464 XP_011512766 NM_012347 NP_036479 NM_033480 NP_258441 NM_033481 NP_258442
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. {ECO:0000269|PubMed:23263282}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23263282}.

Human-FBXO9-cDNA-Clone - DC00312 from Abgent, a WuXi AppTec company

Prices $544.05
Sizes 10 µg
Species Human
Accession BC000650

FBXO9 - MBS1273707 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC000650

Human FBXO9 ORF Clone(NM_033481.3) - CDCR314007 from Creative Biomart

Species Human
Accession NM_033481.3

Human FBXO9 ORF Clone(NM_033481.3) - CDCR314008 from Creative Biomart

Species Human
Accession NM_033481.3

Human FBXO9 ORF Clone(NM_033481.3) - CDCR314009 from Creative Biomart

Species Human
Accession NM_033481.3

Human FBXO9 ORF Clone(NM_012347.4) - CDCL163308 from Creative Biomart

Species Human
Accession NM_012347.4

Human FBXO9 ORF Clone(NM_012347.4) - CDCL163309 from Creative Biomart

Species Human
Accession NM_012347.4

Human FBXO9 ORF clone - CDCL107439 from Creative Biomart

Species Human
Accession NM_012347

Human FBXO9 ORF clone - CDCL107440 from Creative Biomart

Species Human
Accession NM_012347

Human FBXO9 ORF clone - CDCL107441 from Creative Biomart

Species Human
Accession NM_012347

Human FBXO9 ORF clone - CDCL107442 from Creative Biomart

Species Human
Accession NM_012347

Mouse FBXO9 ORF clone - CDCL107443 from Creative Biomart

Species Human
Accession NM_012347

Mouse FBXO9 ORF clone - CDCL107444 from Creative Biomart

Species Human
Accession NM_012347

Human FBXO9 ORF clone - CDCL107445 from Creative Biomart

Species Human
Accession NM_012347

Human FBXO9 ORF clone - CDCL107446 from Creative Biomart

Species Human
Accession NM_012347

Human FBXO9 ORF Clone(NM_033481.3) - CDCR314007 from Creative biogene

Species Human

Human FBXO9 ORF clone (NM_033480.2) - CDCL107441 from Creative biogene

Species Human

Human FBXO9 ORF Clone (BC000650) - CDCS413310 from Creative biogene

Species Human
Accession Q9UK97
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