FBXO9

Gene Symbol	FBXO9
Entrez Gene	26268
Alt Symbol	FBX9, NY-REN-57, VCIA1, dJ341E18.2
Species	Human
Gene Type	protein-coding
Description	F-box protein 9
Other Description	F-box only protein 9|F-box protein Fbx9|cross-immune reaction antigen 1|renal carcinoma antigen NY-REN-57
Swissprots	B3KMM6 Q59EH8 Q9Y593 O75986 Q9UK97 A6NFW3 Q9NT57 Q6PKH7
Accessions	EAX04405 EAX04406 EAX04407 EAX04408 EAX04409 EAX04410 Q9UK97 AA132361 AA890006 AB209833 BAD93070 AF174597 AAF04518 AF176704 AAF03704 AK021559 BAG51038 AK095307 AK095315 AL137520 CAB70786 AY858798 AAW51115 BC000650 AAH00650 BC024973 BX641082 XM_005248995 XP_005249052 XM_005248996 XP_005249053 XM_011514464 XP_011512766 NM_012347 NP_036479 NM_033480 NP_258441 NM_033481 NP_258442
Function	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1. {ECO:0000269|PubMed:23263282}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:23263282}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBX09 full length protein - ab161954 from Abcam Category Protein Source Wheat germ Species Human

Human FBX09 protein fragment - ab161955 from Abcam Category Protein Source Wheat germ Species Human

FBX09 / FBXO9 Antibody Blocking Peptide - LS-E7888 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FBX09 Protein - H00026268-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human FBX09 Protein - H00026268-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FBXO9-Antibody-C-term-Blocking-peptide - BP5562b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FBXO9 Blocking Peptide - 33R-7050 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FBXO9 - H00026268-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FBXO9 - H00026268-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FBXO9 - H00026268-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FBXO9 - H00026268-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FBXO9 fusion protein - Ag1643 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human FBXO9, GST-tagged - FBXO9-12807H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human F-box only protein 9(FBXO9) - CSB-YP891719HU CSB-EP891719HU CSB-BP891719HU CSB-MP891719HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

FBXO9 Peptide, Human - M34GP05620H from Creative Peptides Category Peptide Source Synthetic. Species Human

F-box only protein 9 (FBXO9), Recombinant Protein - MBS1487211 from MyBioSource Category Protein Prices $305.00, $580.00, $950.00, $950.00, $1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,860.00, $1,860.00, $1,860.00, $2,760.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 50 µg (Baculovirus), 500 µg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

FBX09 Recombinant Protein Antigen - NBP2-57524PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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