SRGN

Gene Symbol	SRGN
Entrez Gene	5552
Alt Symbol	PPG, PRG, PRG1
Species	Human
Gene Type	protein-coding
Description	serglycin
Other Description	hematopoetic proteoglycan core peptide|hematopoetic proteoglycan core protein|hematopoietic proteoglycan core protein|p.PG|platelet proteoglycan core protein|proteoglycan 1, secretory granule|proteoglycan protein core for mast cell secretory granule|secretory granule proteoglycan core peptide|secretory granule proteoglycan core protein|serglycin proteoglycan
Swissprots	Q5VW06 B2R4L7 P10124
Accessions	AAA60322 EAW54309 EAW54310 P10124 AI347627 AK311873 BAG34814 BC015516 AAH15516 BC022313 BG057351 BG548665 BP335278 BQ051861 CA308463 CB110512 CD677686 D28395 BAA05761 DQ891442 ABM82368 DQ894620 ABM85546 J03223 AAA60179 X12765 CAA31255 X17042 CAA34900 NM_002727 NP_002718 NR_036430
Function	Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}.
Subcellular Location	Cytoplasmic granule {ECO:0000250}. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SRGN-Over-expression-Lysate - LY15318a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SRGN overexpression lysate - LY419143 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SRGN 293 Cell Lysate - 408961 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SRGN Overexpression Lysate (Native) - NBP2-08075 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Serglycin (h): 293 Lysate - sc-113121 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SRGN Over-expression Lysate Product - GWB-1C6D2D from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human Serglycin / SRGN HEK293 Cell Lysate (WB positive control) - 13648-H33HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Serglycin / SRGN HEK293 Cell Lysate (WB positive control) - 13648-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Serglycin Human Cells Transfected Lysate (positive control) (denatured) - orb174550 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human Serglycin Human Cells Transfected Lysate (positive control) (denatured) - orb173958 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human SRGN Knockdown Stable Cell Line - CSC-DC015150 from Creative biogene Category Cell Line Species Human

Human SRGN Knockout Cell Line-HeLa - CSC-RT1545 from Creative biogene Category Cell Line Species Human

SRGN KO Cell Lysate-HeLa - CLKO-1392 from Creative biogene Category Cell Lysate

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