SRGN

Gene Symbol	SRGN
Entrez Gene	5552
Alt Symbol	PPG, PRG, PRG1
Species	Human
Gene Type	protein-coding
Description	serglycin
Other Description	hematopoetic proteoglycan core peptide|hematopoetic proteoglycan core protein|hematopoietic proteoglycan core protein|p.PG|platelet proteoglycan core protein|proteoglycan 1, secretory granule|proteoglycan protein core for mast cell secretory granule|secretory granule proteoglycan core peptide|secretory granule proteoglycan core protein|serglycin proteoglycan
Swissprots	Q5VW06 B2R4L7 P10124
Accessions	AAA60322 EAW54309 EAW54310 P10124 AI347627 AK311873 BAG34814 BC015516 AAH15516 BC022313 BG057351 BG548665 BP335278 BQ051861 CA308463 CB110512 CD677686 D28395 BAA05761 DQ891442 ABM82368 DQ894620 ABM85546 J03223 AAA60179 X12765 CAA31255 X17042 CAA34900 NM_002727 NP_002718 NR_036430
Function	Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}.
Subcellular Location	Cytoplasmic granule {ECO:0000250}. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

C. elegans PRG1 peptide - ab15827 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Serglycin full length protein - ab113401 from Abcam Category Protein Source E. coli Species Human

Human Serglycin full length protein - ab116976 from Abcam Category Protein Source Wheat germ Species Human

Human Serglycin full length protein - ab116977 from Abcam Category Protein Source Wheat germ Species Human

Human Serglycin full length protein - ab184593 from Abcam Category Protein Source E. coli Species Human

Human Serglycin protein fragment - ab116978 from Abcam Category Protein Source Wheat germ Species Human

SRGN / Serglycin Antibody Blocking Peptide - LS-E1554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SRGN / Serglycin Antibody Blocking Peptide - LS-E14734 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SRGN Recombinant Protein - H00005552-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SRGN Recombinant Protein - H00005552-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SRGN Partial Recombinant Protein - H00005552-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SRGN Protein - NBP1-72483 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

SRGN-Antibody-C-term-Blocking-peptide - BP12292b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SRGN protein (His Tag) - orb139699 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

Human SRGN protein - orb169349 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human SRGN protein (His & MYC Tag) - orb139698 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Serglycin Blocking Peptide - 33R-8219 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SRGN protein (His tag) - 80R-1996 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Serglycin / PRG1 (28-158, His-tag) - AR50067PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Serglycin / PRG1 (28-158, His-tag) - AR50067PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Serglycin / PRG1 - H00005552-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Serglycin / PRG1 - H00005552-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Serglycin / PRG1 - H00005552-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Serglycin / PRG1 - H00005552-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Serglycin / PRG1 - H00005552-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

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