SRGN

Gene Symbol SRGN
Entrez Gene 5552
Alt Symbol PPG, PRG, PRG1
Species Human
Gene Type protein-coding
Description serglycin
Other Description hematopoetic proteoglycan core peptide|hematopoetic proteoglycan core protein|hematopoietic proteoglycan core protein|p.PG|platelet proteoglycan core protein|proteoglycan 1, secretory granule|proteoglycan protein core for mast cell secretory granule|secretory granule proteoglycan core peptide|secretory granule proteoglycan core protein|serglycin proteoglycan
Swissprots Q5VW06 B2R4L7 P10124
Accessions AAA60322 EAW54309 EAW54310 P10124 AI347627 AK311873 BAG34814 BC015516 AAH15516 BC022313 BG057351 BG548665 BP335278 BQ051861 CA308463 CB110512 CD677686 D28395 BAA05761 DQ891442 ABM82368 DQ894620 ABM85546 J03223 AAA60179 X12765 CAA31255 X17042 CAA34900 NM_002727 NP_002718 NR_036430
Function Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}.
Subcellular Location Cytoplasmic granule {ECO:0000250}. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.

Serglycin (C-11) - sc-374657 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Serglycin (C-11): sc-374657. Western blot analysis of Serglycin expression in non-transfected 293: sc-110760 (A), human Serglycin transfected 293: sc-113121 (B) and HL-60 (C) whole cell lysates.

Serglycin (H-9) - sc-393521 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Serglycin (H-9): sc-393521. Western blot analysis of Serglycin expression in non-transfected 293: sc-110760 (A), human Serglycin transfected 293: sc-113121 (B), HL-60 (C) and THP-1 (D) whole cell lysates.

Serglycin (D-19) - sc-28008 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Serglycin (D-19): sc-28008. Western blot analysis of Serglycin expression in HL-60 (A) and THP-1 (B) whole cell lysates.

Serglycin (FL-158) - sc-292311 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Serglycin (FL-158): sc-292311. Western blot analysis of Serglycin expression in non-transfected: sc-110760 (A) and human Serglycin transfected: sc-113121 (B) 293 whole cell lysates.

Serglycin (N-13) - sc-28007 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Serglycin (N-13): sc-28007. Western blot analysis of Serglycin expression in non-transfected: sc-110760 (A) and human Serglycin transfected: sc-113121 (B) 293 whole cell lysates.

Anti-Serglycin antibody - ab76512 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing Jurkat cells stained with ab76512 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab76512, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in Jurkat cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Serglycin antibody - ab123051 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Serglycin antibody (ab123051) at 1 µg/ml + Jurkat cell lysate at 10 µg

Anti-SRGN / Serglycin Antibody (N-Terminus) - LS-C146031 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRGN antibody LS-C146031 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-SRGN / Serglycin Antibody (aa71-120) - LS-C110515 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRGN antibody LS-C110515 Western blot of Transfected 293T cell lysate.

Anti-SRGN / Serglycin Antibody (aa118-148, AP) - LS-C270348 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa118-148, APC) - LS-C270350 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa118-148, Biotin) - LS-C270351 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa118-148, FITC) - LS-C270352 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa118-148, Azide-free, HRP) - LS-C270353 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa118-148, PE) - LS-C270354 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa28-152, Biotin) - LS-C301129 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa28-152, FITC) - LS-C302504 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (aa118-148) - LS-C325380 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRGN / Serglycin Antibody (clone 1D8) - LS-C197981 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D8
Detection limit for recombinant GST tagged SRGN is 0.3 ng/ml as a capture antibody.

Anti-SRGN / Serglycin Antibody (aa28-152) - LS-C296387 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SRGN / Serglycin.

Anti-SRGN / Serglycin Antibody (aa118-148) - LS-C161499 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
SRGN Antibody western blot of HeLa cell line lysates (35 ug/lane). The SRGN antibody detected the SRGN protein (arrow).

Anti-SRGN / Serglycin Antibody - LS-C334976 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cell using SRGN antibody. Blue: DAPI for nuclear staining.

SRGN Antibody - NBP1-80886 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal

SRGN Antibody - NBP1-80447 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SRGN Antibody [NBP1-80447] - Transfected 293T cell lysate, concentration 0.2-1 ug/ml.

SRGN Polyclonal Antibody - bs-6789R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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