| Gene Symbol | SRGN |
|---|---|
| Entrez Gene | 5552 |
| Alt Symbol | PPG, PRG, PRG1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | serglycin |
| Other Description | hematopoetic proteoglycan core peptide|hematopoetic proteoglycan core protein|hematopoietic proteoglycan core protein|p.PG|platelet proteoglycan core protein|proteoglycan 1, secretory granule|proteoglycan protein core for mast cell secretory granule|secretory granule proteoglycan core peptide|secretory granule proteoglycan core protein|serglycin proteoglycan |
| Swissprots | Q5VW06 B2R4L7 P10124 |
| Accessions | AAA60322 EAW54309 EAW54310 P10124 AI347627 AK311873 BAG34814 BC015516 AAH15516 BC022313 BG057351 BG548665 BP335278 BQ051861 CA308463 CB110512 CD677686 D28395 BAA05761 DQ891442 ABM82368 DQ894620 ABM85546 J03223 AAA60179 X12765 CAA31255 X17042 CAA34900 NM_002727 NP_002718 NR_036430 |
| Function | Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}. |
| Subcellular Location | Cytoplasmic granule {ECO:0000250}. Secreted, extracellular space. Golgi apparatus. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation. |