| Gene Symbol |
TWIST2
|
| Entrez Gene |
117581
|
| Alt Symbol |
DERMO1, FFDD3, SETLSS, bHLHa39
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
twist family bHLH transcription factor 2
|
| Other Description |
class A basic helix-loop-helix protein 39|dermis-expressed protein 1|twist basic helix-loop-helix transcription factor 2|twist homolog 2|twist-related bHLH protein Dermo1|twist-related protein 2
|
| Swissprots |
Q8WVJ9 Q3SYL6
|
| Accessions |
EAW71163 EAW71164 Q8WVJ9 AW072674 BC017907 AAH17907 BC033168 AAH33168 BC103755 AAI03756 BU615717 DB359681 DQ892806 ABM83732 DQ896053 ABM87052 XM_006712242 XP_006712305 NM_001271893 NP_001258822 NM_057179 NP_476527
|
| Function |
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. {ECO:0000250, ECO:0000269|PubMed:11062344}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm {ECO:0000269|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
|
| Tissue Specificity |
In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. {ECO:0000269|PubMed:11062344}.
|
| Top Pathways |
Proteoglycans in cancer
|
![Western Blot: Twist2 Overexpression Lysate (Adult Normal) [NBL1-17460] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Twist2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9394_Twist2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17460-img0002.jpg)