TWIST2

Gene Symbol TWIST2
Entrez Gene 117581
Alt Symbol DERMO1, FFDD3, SETLSS, bHLHa39
Species Human
Gene Type protein-coding
Description twist family bHLH transcription factor 2
Other Description class A basic helix-loop-helix protein 39|dermis-expressed protein 1|twist basic helix-loop-helix transcription factor 2|twist homolog 2|twist-related bHLH protein Dermo1|twist-related protein 2
Swissprots Q8WVJ9 Q3SYL6
Accessions EAW71163 EAW71164 Q8WVJ9 AW072674 BC017907 AAH17907 BC033168 AAH33168 BC103755 AAI03756 BU615717 DB359681 DQ892806 ABM83732 DQ896053 ABM87052 XM_006712242 XP_006712305 NM_001271893 NP_001258822 NM_057179 NP_476527
Function Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. {ECO:0000250, ECO:0000269|PubMed:11062344}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm {ECO:0000269|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Tissue Specificity In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. {ECO:0000269|PubMed:11062344}.
Top Pathways Proteoglycans in cancer

twist2 CRISPR/Cas9 KO Plasmid (h) - sc-414117 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist2 HDR Plasmid (h) - sc-414117-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist2 Double Nickase Plasmid (h) - sc-414117-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist2 Double Nickase Plasmid (h2) - sc-414117-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist CRISPR Activation Plasmid (h) - sc-414117-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist2 CRISPR Activation Plasmid (h2) - sc-414117-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist2 Lentiviral Activation Particles (h) - sc-414117-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist2 Lentiviral Activation Particles (h2) - sc-414117-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

twist2 siRNA (h) - sc-106728 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

twist2 shRNA Plasmid (h) - sc-106728-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

twist2 shRNA (h) Lentiviral Particles - sc-106728-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Twist-2 RNAi - H00117581-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU227201 from Sigma-Aldrich

Category siRNA
Prices $140.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22293 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22293 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TWIST2 siRNA (Human) - CRJ4573 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TWIST2 - MBS8200052 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TWIST2 (NM_057179.2) - SHH438072 from Creative biogene

Category siRNA
Species Reactivities Human

Human TWIST2 siRNA - orb275074 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TWIST2 shRNA Plasmid (Human) - CHJ4573 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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