TWIST2

Gene Symbol	TWIST2
Entrez Gene	117581
Alt Symbol	DERMO1, FFDD3, SETLSS, bHLHa39
Species	Human
Gene Type	protein-coding
Description	twist family bHLH transcription factor 2
Other Description	class A basic helix-loop-helix protein 39|dermis-expressed protein 1|twist basic helix-loop-helix transcription factor 2|twist homolog 2|twist-related bHLH protein Dermo1|twist-related protein 2
Swissprots	Q8WVJ9 Q3SYL6
Accessions	EAW71163 EAW71164 Q8WVJ9 AW072674 BC017907 AAH17907 BC033168 AAH33168 BC103755 AAI03756 BU615717 DB359681 DQ892806 ABM83732 DQ896053 ABM87052 XM_006712242 XP_006712305 NM_001271893 NP_001258822 NM_057179 NP_476527
Function	Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. {ECO:0000250, ECO:0000269|PubMed:11062344}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm {ECO:0000269|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Tissue Specificity	In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. {ECO:0000269|PubMed:11062344}.
Top Pathways	Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Twist2 full length protein - ab132641 from Abcam Category Protein Source Wheat germ Species Human

Human Twist2 peptide - ab86241 from Abcam Category Peptide

Human Twist2 protein fragment - ab153585 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Twist-2 Protein - H00117581-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Twist-2 Protein - H00117581-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TWIST2 - H00117581-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TWIST2 - H00117581-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TWIST2 - H00117581-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TWIST2 - H00117581-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TWIST2 fusion protein - ag2348 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Twist-related protein 2(TWIST2) - CSB-YP848823HU CSB-EP848823HU CSB-BP848823HU CSB-MP848823HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TWIST2 - TP305006 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TWIST2 Peptide, Human - M34GP16884H from Creative Peptides Category Peptide Source Synthetic. Species Human

Twist-2 Recombinant Protein Antigen - NBP2-56209PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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