TWIST2

Gene Symbol	TWIST2
Entrez Gene	117581
Alt Symbol	DERMO1, FFDD3, SETLSS, bHLHa39
Species	Human
Gene Type	protein-coding
Description	twist family bHLH transcription factor 2
Other Description	class A basic helix-loop-helix protein 39\|dermis-expressed protein 1\|twist basic helix-loop-helix transcription factor 2\|twist homolog 2\|twist-related bHLH protein Dermo1\|twist-related protein 2
Swissprots	Q8WVJ9 Q3SYL6
Accessions	EAW71163 EAW71164 Q8WVJ9 AW072674 BC017907 AAH17907 BC033168 AAH33168 BC103755 AAI03756 BU615717 DB359681 DQ892806 ABM83732 DQ896053 ABM87052 XM_006712242 XP_006712305 NM_001271893 NP_001258822 NM_057179 NP_476527
Function	Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. {ECO:0000250, ECO:0000269\|PubMed:11062344}.
Subcellular Location	Nucleus {ECO:0000255\|PROSITE- ProRule:PRU00981, ECO:0000269\|PubMed:11062344}. Cytoplasm {ECO:0000269\|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
Tissue Specificity	In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liver. Expression also detected in the secretory ependymal epithelium of the choroid plexus primordium. In the adult, expressed in secreting glandular tissues and tubules. {ECO:0000269\|PubMed:11062344}.
Top Pathways	Proteoglycans in cancer

Anti-Twist2 antibody - ab66031 from Abcam

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Twist2 antibody (ab66031) at 1 µg/mlLane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lane 3 : Testis (Human) Tissue Lysate - adult normal tissue (ab30257)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Twist2 antibody - ab57997 from Abcam

Prices	$390.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Twist2 antibody (ab57997) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human liver.

Anti-Twist2 antibody - ab173453 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Twist2 antibody (ab173453) at 1 µg/mlLane 1 : Twist2 transfected 293T cell line lysateLane 2 : Non transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L), Peroxidase Conjugated at 1/7500 dilution

Anti-Twist2 antibody [3C8] - ab115582 from Abcam

Host	Mouse
Clonality	Monoclonal
Clone	3C8

All lanes : Anti-Twist2 antibody [3C8] (ab115582) at 1/500 dilutionLane 1 : 293T cell line, transfected with Twist2Lane 2 : 293T cell line, non-transfected

Twist-2 Antibody (3C8) - H00117581-M01 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C8

Western Blot: Twist-2 Antibody (3C8) [H00117581-M01] - Analysis of TWIST2 expression in transfected 293T cell line by TWIST2 monoclonal antibody (M01), clone 3C8.Lane 1: TWIST2 transfected lysate(18.1 KDa).Lane 2: Non-transfected lysate.

Twist-2 Antibody - AF6249 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Sheep
Clonality	Polyclonal

Twist-2 Antibody - H00117581-D01P from Novus Biologicals

Prices	$399.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: Twist-2 Antibody [H00117581-D01P] - Analysis of TWIST2 expression in transfected 293T cell line by TWIST2 polyclonal antibody.Lane 1: TWIST2 transfected lysate(18.10 KDa).Lane 2: Non-transfected lysate.

Twist-2 Antibody - H00117581-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot analysis of TWIST2 expression in transfected 293T cell line by TWIST2 MaxPab polyclonal antibody. Lane 1: TWIST2 transfected lysate (18.10 KDa). Lane 2: Non-transfected lysate.

Twist-2 Antibody (3C12) - H00117581-M12 from Novus Biologicals

Prices	$349.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C12

Twist-2 Antibody (3B2) - H00117581-M20A from Novus Biologicals

Prices	$349.00
Sizes	200 µl
Host	Mouse
Clonality	Monoclonal
Clone	3B2

Twist-2 Antibody (1E2) - H00117581-M06 from Novus Biologicals

Prices	$359.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1E2

Western Blot: Twist-2 Antibody (1E2) [H00117581-M06] - Analysis of TWIST2 expression in transfected 293T cell line by TWIST2 monoclonal antibody (M06), clone 1E2. Lane 1: TWIST2 transfected lysatE (18.1 KDa). Lane 2: Non-transfected lysate.

Twist2 Polyclonal Antibody - bs-4173R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Monoclonal Anti-TWIST2 antibody produced in mouse - SAB1405347 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1E2

<B>Immunofluorescence</B><BR/>Monoclonal Anti-TWIST2: <B>Cat. No. SAB1405347</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Monoclonal Anti-TWIST2 antibody produced in mouse - SAB1408856 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C12

<B>Immunoblotting</B><BR/>Monoclonal Anti-TWIST2: <B>Cat. No. SAB1408856</B>: Antibody concentration: 1 μg/mL. Specific band of ~32.6 kDa using immunogen protein lysate.

Monoclonal Anti-TWIST2 antibody produced in mouse - WH0117581M1 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C8

<B>Immunoblotting</B><BR/>Monoclonal Anti-TWIST2, <B>Cat. No. WH0117581M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~43.71 kDa using immunogen protein lysate.

Anti-TWIST2 antibody produced in rabbit - SAB1401972 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Polyclonal Anti-TWIST2, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401972</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~18.10 kDa using TWIST2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

TWIST2-Antibody-monoclonal-M01 - AT4412a from Abgent, a WuXi AppTec company

Prices	$315.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	3C8

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (43.34 KDa) .

Human Twist-2 Antibody - AF6249 from R&D Systems

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Sheep

Twist-2 in A549 Human Cell Line. Twist-2 was detected in immersion fixed A549 human lung carcinoma cells treated with Recombinant Human TGF-beta 1 (Catalog # 240-B ) using Human Twist-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6249) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel; Catalog # NL010 ) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei and cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips .

Human Twist-2 Affinity Purified Polyclonal Ab, Sheep IgG - AF6249-SP from R&D Systems

Host	Sheep
Clonality	Polyclonal

Twist2 antibody - orb69642 from Biorbyt

Prices	$417.00, $536.00
Sizes	50 μl, 100 μl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed and paraffin embedded human kidney tissue using Twist2 antibody

Twist2 antibody - 20R-2784 from Fitzgerald

Prices	$225.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Twist2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-4173R-A350 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Twist2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-4173R-A488 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Twist2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-4173R-A555 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Twist2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-4173R-A647 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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