CDK12

Gene Symbol	CDK12
Entrez Gene	51755
Alt Symbol	CRK7, CRKR, CRKRS
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 12
Other Description	CDC2-related protein kinase 7|Cdc2-related kinase, arginine/serine-rich|cell division cycle 2-related protein kinase 7|cell division protein kinase 12
Swissprots	O94978 Q9NYV4 B9EIQ6 B4DYX4 A7E2B2
Accessions	EAW60576 EAW60577 Q9NYV4 AB020711 BAA74927 AF227198 AAF36401 AK096059 AK302645 BAG63886 BC140854 AAI40855 BC150265 AAI50266 BE003756 BM557102 CB049262 DA026139 LK938129 XM_005257456 XP_005257513 XM_005257458 XP_005257515 XM_011524892 XP_011523194 XM_011524893 XP_011523195 XM_011524894 XP_011523196 XM_011524895 XP_011523197 XM_011524896 XP_011523198 XM_011524897 XP_011523199 XM_011524898 XP_011523200 XM_011524899 XP_011523201 XM_011524900 XP_011523202 XM_011524901 XP_011523203 XM_011524902 XP_011523204 XM_011524903 XP_011523205 XM_011524904 XP_011523206 XM_011524905 XP_011523207 XM_011524906 XP_011523208 XM_011524907 XP_011523209 NM_015083 NP_055898 NM_016507 NP_057591
Function	Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Subcellular Location	Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11683387}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CDK12 Antibody - 11973 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

CrkRS (N-16) - sc-32643 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CrkRS (R-12) - sc-81834 from Santa Cruz Biotechnology Prices $295.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

Anti-CrkRS antibody - ab57311 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CrkRS antibody - ab37914 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (N-Terminus) - LS-C99890 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (Internal) IHC-plus™ - LS-A7350 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (C-Terminus) IHC-plus™ - LS-A7320 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (clone 3C1) - LS-C105145 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3C1

Anti-CDK12 / CRKRS Antibody (N-Terminus, AP) - LS-C243903 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (N-Terminus, Biotin) - LS-C243905 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (N-Terminus, APC) - LS-C243904 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (N-Terminus, PE) - LS-C243910 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (N-Terminus, FITC) - LS-C243906 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (aa1-50) - LS-C288466 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (N-Terminus, Azide-free, HRP) - LS-C247483 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CDK12 / CRKRS Antibody (N-Terminus) - LS-C330372 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

CrkRS Antibody (2F6) - H00051755-M02 from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2F6

CrkRS Antibody - NB100-87011 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CrkRS Antibody - NBP1-85451 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CrkRS Antibody (3C1) - H00051755-M04 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3C1

CrkRS Antibody - NLS7350 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

CrkRS Antibody (1H4) - H00051755-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1H4

CrkRS Antibody (2F6) - H00051755-M02A from Novus Biologicals Prices $349.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 2F6

CrkRS Antibody - NB100-87012 from Novus Biologicals Host Rabbit Clonality Polyclonal

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