CDK12

Gene Symbol	CDK12
Entrez Gene	51755
Alt Symbol	CRK7, CRKR, CRKRS
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 12
Other Description	CDC2-related protein kinase 7|Cdc2-related kinase, arginine/serine-rich|cell division cycle 2-related protein kinase 7|cell division protein kinase 12
Swissprots	O94978 Q9NYV4 B9EIQ6 B4DYX4 A7E2B2
Accessions	EAW60576 EAW60577 Q9NYV4 AB020711 BAA74927 AF227198 AAF36401 AK096059 AK302645 BAG63886 BC140854 AAI40855 BC150265 AAI50266 BE003756 BM557102 CB049262 DA026139 LK938129 XM_005257456 XP_005257513 XM_005257458 XP_005257515 XM_011524892 XP_011523194 XM_011524893 XP_011523195 XM_011524894 XP_011523196 XM_011524895 XP_011523197 XM_011524896 XP_011523198 XM_011524897 XP_011523199 XM_011524898 XP_011523200 XM_011524899 XP_011523201 XM_011524900 XP_011523202 XM_011524901 XP_011523203 XM_011524902 XP_011523204 XM_011524903 XP_011523205 XM_011524904 XP_011523206 XM_011524905 XP_011523207 XM_011524906 XP_011523208 XM_011524907 XP_011523209 NM_015083 NP_055898 NM_016507 NP_057591
Function	Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Subcellular Location	Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11683387}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cyclin-dependent kinase 12 (CRKRS), Human, ELISA Kit - E01C2070 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Cyclin-dependent kinase 12, CDK12, Human, ELISA Kit - E6889h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 78-5000 pg/mL

Cyclin dependent kinase 12 (CRKRS), ELISA Kit - MBS7230893 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse CDK12 / CRKRS ELISA Kit (Custom ELISA) - LS-F20087 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Bovine CDK12 / CRKRS ELISA Kit (Custom ELISA) - LS-F20088 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Rat CDK12 / CRKRS ELISA Kit (Custom ELISA) - LS-F20086 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Cyclin-dependent kinase 12, ELISA Kit - MBS288458 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78.0 pg/mL -5000 pg/mL.

Human Cyclin-dependent kinase 12 ELISA Kit - abx251707 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human CDK12 / CRKRS ELISA Kit (Sandwich ELISA) - LS-F13113 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

Human Cyclin-dependent kinase 12 ELISA Kit - EKE54693 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 34 pg/mL Range 78-5000 pg/mL

CDK12 - EKH4700 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

CDK12 ELISA Kit (Human) (OKEH01800) - OKEH01800 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 34 pg/mL Range 78 - 5,000 pg/mL

Human CRKRS ELISA Kit - E010551 from Biobool Category ELISA Kit

Human CDK12 ELISA Kit - E010657 from Biobool Category ELISA Kit

Human Cyclin-dependent kinase 12 ELISA Kit - EK4739 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 0.1ng/mL Range 0.312-20 ng/mL

Cyclin-dependent kinase 12, ELISA Kit - MBS761602 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

Cyclin-dependent kinase 12, ELISA Kit - MBS9428565 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 34pg/mL Range 78-5000 pg/mL

Human CDK12 / CRKRS ELISA Kit (Sandwich ELISA) - LS-F35287 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 78-5000 pg/ml

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