CDK12

Gene Symbol	CDK12
Entrez Gene	51755
Alt Symbol	CRK7, CRKR, CRKRS
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 12
Other Description	CDC2-related protein kinase 7|Cdc2-related kinase, arginine/serine-rich|cell division cycle 2-related protein kinase 7|cell division protein kinase 12
Swissprots	O94978 Q9NYV4 B9EIQ6 B4DYX4 A7E2B2
Accessions	EAW60576 EAW60577 Q9NYV4 AB020711 BAA74927 AF227198 AAF36401 AK096059 AK302645 BAG63886 BC140854 AAI40855 BC150265 AAI50266 BE003756 BM557102 CB049262 DA026139 LK938129 XM_005257456 XP_005257513 XM_005257458 XP_005257515 XM_011524892 XP_011523194 XM_011524893 XP_011523195 XM_011524894 XP_011523196 XM_011524895 XP_011523197 XM_011524896 XP_011523198 XM_011524897 XP_011523199 XM_011524898 XP_011523200 XM_011524899 XP_011523201 XM_011524900 XP_011523202 XM_011524901 XP_011523203 XM_011524902 XP_011523204 XM_011524903 XP_011523205 XM_011524904 XP_011523206 XM_011524905 XP_011523207 XM_011524906 XP_011523208 XM_011524907 XP_011523209 NM_015083 NP_055898 NM_016507 NP_057591
Function	Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
Subcellular Location	Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11683387}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CrkRS protein fragment - ab153361 from Abcam Category Protein Source Wheat germ Species Human

CDK12 / CRKRS Antibody Blocking Peptide - LS-E9030 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK12 / CRKRS Antibody Blocking Peptide - LS-E29254 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CDK12 / CRKRS Antibody Blocking Peptide - LS-E29259 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human CrkRS Protein - H00051755-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CrkRS Peptide - P2539 from Novus Biologicals Category Peptide Species Human

CrkRS-CRK7-Antibody-N-term-Blocking-peptide - BP7533a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CRKRS / CRK7 - H00051755-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CRKRS / CRK7 - H00051755-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human Cyclin-dependent kinase 12(CDK12) ,partial - CSB-YP882147HU CSB-EP882147HU CSB-BP882147HU CSB-MP882147HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human CDK12+CyclinK protein fragment - ab204096 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human CrkRS protein fragment - ab204102 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

CrkRS Recombinant Protein Antigen - NBP1-85451PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CRKRS fusion protein - Ag25323 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

CrkRS-CRK7-Antibody-C-term-Blocking-peptide - BP7533b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDK12 Peptide, Human - M34GP02861H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cyclin-dependent kinase 12 (CDK12), partial, Recombinant Protein - MBS1445655 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,655.00, $1,655.00, $2,115.00, $2,115.00, $2,150.00, $3,260.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human CDK2 Protein, GST-tagged - CDK12-11H from Creative Biomart Category Protein Source Insect cells Species Human

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