| Gene Symbol |
CDK12
|
| Entrez Gene |
51755
|
| Alt Symbol |
CRK7, CRKR, CRKRS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 12
|
| Other Description |
CDC2-related protein kinase 7|Cdc2-related kinase, arginine/serine-rich|cell division cycle 2-related protein kinase 7|cell division protein kinase 12
|
| Swissprots |
O94978 Q9NYV4 B9EIQ6 B4DYX4 A7E2B2
|
| Accessions |
EAW60576 EAW60577 Q9NYV4 AB020711 BAA74927 AF227198 AAF36401 AK096059 AK302645 BAG63886 BC140854 AAI40855 BC150265 AAI50266 BE003756 BM557102 CB049262 DA026139 LK938129 XM_005257456 XP_005257513 XM_005257458 XP_005257515 XM_011524892 XP_011523194 XM_011524893 XP_011523195 XM_011524894 XP_011523196 XM_011524895 XP_011523197 XM_011524896 XP_011523198 XM_011524897 XP_011523199 XM_011524898 XP_011523200 XM_011524899 XP_011523201 XM_011524900 XP_011523202 XM_011524901 XP_011523203 XM_011524902 XP_011523204 XM_011524903 XP_011523205 XM_011524904 XP_011523206 XM_011524905 XP_011523207 XM_011524906 XP_011523208 XM_011524907 XP_011523209 NM_015083 NP_055898 NM_016507 NP_057591
|
| Function |
Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.
|
| Subcellular Location |
Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11683387}.
|