CDK12
| Gene Symbol | CDK12 |
|---|---|
| Entrez Gene | 51755 |
| Alt Symbol | CRK7, CRKR, CRKRS |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 12 |
| Other Description | CDC2-related protein kinase 7|Cdc2-related kinase, arginine/serine-rich|cell division cycle 2-related protein kinase 7|cell division protein kinase 12 |
| Swissprots | O94978 Q9NYV4 B9EIQ6 B4DYX4 A7E2B2 |
| Accessions | EAW60576 EAW60577 Q9NYV4 AB020711 BAA74927 AF227198 AAF36401 AK096059 AK302645 BAG63886 BC140854 AAI40855 BC150265 AAI50266 BE003756 BM557102 CB049262 DA026139 LK938129 XM_005257456 XP_005257513 XM_005257458 XP_005257515 XM_011524892 XP_011523194 XM_011524893 XP_011523195 XM_011524894 XP_011523196 XM_011524895 XP_011523197 XM_011524896 XP_011523198 XM_011524897 XP_011523199 XM_011524898 XP_011523200 XM_011524899 XP_011523201 XM_011524900 XP_011523202 XM_011524901 XP_011523203 XM_011524902 XP_011523204 XM_011524903 XP_011523205 XM_011524904 XP_011523206 XM_011524905 XP_011523207 XM_011524906 XP_011523208 XM_011524907 XP_011523209 NM_015083 NP_055898 NM_016507 NP_057591 |
| Function | Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}. |
| Subcellular Location | Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11683387}. |
CrkRS CRISPR/Cas9 KO Plasmid (h) - sc-402238 from Santa Cruz Biotechnology
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CrkRS HDR Plasmid (h) - sc-402238-HDR from Santa Cruz Biotechnology
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CrkRS Double Nickase Plasmid (h) - sc-402238-NIC from Santa Cruz Biotechnology
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CrkRS Double Nickase Plasmid (h2) - sc-402238-NIC-2 from Santa Cruz Biotechnology
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CrkRS CRISPR Activation Plasmid (h) - sc-402238-ACT from Santa Cruz Biotechnology
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CrkRS CRISPR Activation Plasmid (h2) - sc-402238-ACT-2 from Santa Cruz Biotechnology
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CrkRS Lentiviral Activation Particles (h) - sc-402238-LAC from Santa Cruz Biotechnology
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CrkRS Lentiviral Activation Particles (h2) - sc-402238-LAC-2 from Santa Cruz Biotechnology
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CrkRS siRNA (h) - sc-44343 from Santa Cruz Biotechnology
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CrkRS shRNA Plasmid (h) - sc-44343-SH from Santa Cruz Biotechnology
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CrkRS shRNA (h) Lentiviral Particles - sc-44343-V from Santa Cruz Biotechnology
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CrkRS RNAi - H00051755-R02 from Novus Biologicals
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MISSION® esiRNA - EHU021801 from Sigma-Aldrich
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MISSION® siRNA - SIHK0493 from Sigma-Aldrich
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MISSION® siRNA - SIHK0491 from Sigma-Aldrich
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MISSION® siRNA - SIHK0492 from Sigma-Aldrich
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MISSION® siRNA - SIHK0490 from Sigma-Aldrich
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MISSION® siRNA - SIHK0495 from Sigma-Aldrich
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MISSION® siRNA - SIHK0494 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5838 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5838 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07805 from Sigma-Aldrich
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CDK12 siRNA (Human) - CRH9935 from Cohesion Biosciences
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CDK12 - MBS8238222 from MyBioSource
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shRNA set against Human CDK12 (NM_016507.2) - SHH260497 from Creative biogene
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