DDIT4

Gene Symbol DDIT4
Entrez Gene 54541
Alt Symbol Dig2, REDD-1, REDD1
Species Human
Gene Type protein-coding
Description DNA-damage-inducible transcript 4
Other Description DNA damage-inducible transcript 4 protein|HIF-1 responsive protein RTP801|protein regulated in development and DNA damage response 1
Swissprots Q9H0S3 Q9NX09
Accessions EAW54452 EAW54453 Q9NX09 AF335324 AAL38424 AK000507 BAA91214 AL136668 CAB66603 AM392607 CAL37485 AY090097 AAM10442 BC000708 AAH00708 BC007714 AAH07714 BC015236 AAH15236 BE882343 BM843387 CN428398 DQ890984 ABM81910 DQ894159 ABM85085 NM_019058 NP_061931
Function Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. {ECO:0000250, ECO:0000
Subcellular Location Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:12453409}.
Tissue Specificity Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). {ECO:0000269|PubMed:11884613, ECO:0000269|PubMed:12453409, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067}.
Top Pathways PI3K-Akt signaling pathway, MicroRNAs in cancer, mTOR signaling pathway

DNA damage-inducible transcript 4 protein (DDIT4), Human, ELISA Kit - CSB-EL006590HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 0.039 ng/ml
Range 0.156 ng/ml-10 ng/ml

DDIT4 (Human) Matched Antibody Pair - H00054541-AP21 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

DNA-damage-inducible transcript 4, ELISA Kit - MBS944137 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human DDIT4 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 0.156 ng/ml -10 ng/ml.

Human DNA damage-inducible transcript 4 protein(DDIT4) ELISA kit - CSB-EL006590HU from Cusabio

Category ELISA Kit
Sensitivity 0.039 ng/ml
Range 0.156 ng/ml-10 ng/ml

Human DDIT4 ELISA Kit - E012181 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human DDIT4 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the m

DDIT4 ELISA Kit (Human) (OKCA00657) - OKCA00657 from Aviva Systems Biology

Category ELISA Kit
Prices $590.00
Sizes 96 wells
Sensitivity 0.039 ng/mL
Range 0.156 ng/mL-10 ng/mL

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9358646 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9348979 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9366053 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9360665 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9366213 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9350726 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9366484 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9352425 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9355616 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9359761 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9359973 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9352162 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9360025 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9364623 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9351033 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9350197 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9354284 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9356340 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA Damage-Inducible Transcript 4 (DDIT4), ELISA Kit - MBS9365935 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Search more