DDIT4
| Gene Symbol | DDIT4 |
|---|---|
| Entrez Gene | 54541 |
| Alt Symbol | Dig2, REDD-1, REDD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DNA-damage-inducible transcript 4 |
| Other Description | DNA damage-inducible transcript 4 protein|HIF-1 responsive protein RTP801|protein regulated in development and DNA damage response 1 |
| Swissprots | Q9H0S3 Q9NX09 |
| Accessions | EAW54452 EAW54453 Q9NX09 AF335324 AAL38424 AK000507 BAA91214 AL136668 CAB66603 AM392607 CAL37485 AY090097 AAM10442 BC000708 AAH00708 BC007714 AAH07714 BC015236 AAH15236 BE882343 BM843387 CN428398 DQ890984 ABM81910 DQ894159 ABM85085 NM_019058 NP_061931 |
| Function | Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. {ECO:0000250, ECO:0000 |
| Subcellular Location | Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:12453409}. |
| Tissue Specificity | Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). {ECO:0000269|PubMed:11884613, ECO:0000269|PubMed:12453409, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067}. |
| Top Pathways | PI3K-Akt signaling pathway, MicroRNAs in cancer, mTOR signaling pathway |
Human DDIT4 full length protein - ab40031 from Abcam
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DDIT4 / REDD1 Antibody Blocking Peptide - LS-E8162 from LifeSpan Bioscience
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DDIT4 / REDD1 Antibody Blocking Peptide - LS-E30460 from LifeSpan Bioscience
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DDIT4 / REDD1 Antibody Blocking Peptide - LS-E30464 from LifeSpan Bioscience
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DDIT4 Recombinant Protein - H00054541-P01 from Novus Biologicals
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DDIT4 Partial Recombinant Protein - H00054541-Q01 from Novus Biologicals
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DDIT4 Peptide - NBP1-76382PEP from Novus Biologicals
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DDIT4 Blocking Peptide - NBP1-77321PEP from Novus Biologicals
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Recombinant Human DDIT4 Protein - NBP1-50976 from Novus Biologicals
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DDIT4-Antibody-N-term-Blocking-Peptide - BP6268a from Abgent, a WuXi AppTec company
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DDIT4 Protein (OPPA00059) - OPPA00059 from Aviva Systems Biology
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Human DDIT4 protein - orb168202 from Biorbyt
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DDIT4 protein (His tag) - 80R-1654 from Fitzgerald
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DDIT4 (1-232, His-tag) - AR09836PU-L from Acris Antibodies
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DDIT4 (1-232, His-tag) - AR09836PU-N from Acris Antibodies
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DDIT4 - H00054541-P01-10 from Acris Antibodies
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DDIT4 - H00054541-P01-25 from Acris Antibodies
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DDIT4 - H00054541-Q01-10 from Acris Antibodies
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DDIT4 - H00054541-Q01-25 from Acris Antibodies
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DDIT4 Control Peptide - AP30744CP-N from Acris Antibodies
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DDIT4 Control Peptide - AP30745CP-N from Acris Antibodies
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DDIT4, 1-232aa, Human, His tag, E.coli - 01-P0896 from ARP American Research Products
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RTP801 Peptide - 4509P from ProSci
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RTP801 Peptide - 4495P from ProSci
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REDD1 fusion protein - Ag0965 from Proteintech Group
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