STK11

Gene Symbol STK11
Entrez Gene 6794
Alt Symbol LKB1, PJS, hLKB1
Species Human
Gene Type protein-coding
Description serine/threonine kinase 11
Other Description liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11
Swissprots E7EW76 Q15831 B2RBX7
Accessions AAB97833 AAC15742 AAF97257 EAW69538 EAW69539 EAW69540 Q15831 AB209553 BAD92790 AF035625 AAC39527 AF217978 AAG17221 AJ844634 CAH59749 AK128518 AK314858 BAG37374 BC007981 AAH07981 BC019334 AAH19334 BM993274 BQ222023 BU174122 BU739451 DQ893232 ABM84158 DQ896561 ABM87560 EF644172 ABR45718 GU573916 ADD71158 U63333 AAB05809 XM_005259617 XP_005259674 XM_005259618 XP_005259675 XM_011528209 XP_011526511 XR_936204 NM_000455 NP_000446
Function Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA d
Subcellular Location Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Strongest expression in testis and fetal liver.
Top Pathways Adipocytokine signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, mTOR signaling pathway

Phospho-LKB1 (Ser428) (C67A3) Rabbit mAb - 3482 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C67A3
Western blot analysis of extracts from various cell lines, untreated or treated with TPA #9905 and UV, using Phospho-LKB1 (Ser428) (C67A3) Rabbit mAb (upper) and LKB1 (D60C5) Rabbit mAb #3047 (lower).

Phospho-LKB1 (Thr189) Antibody - 3054 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, untransfected or transfected with Wild-type LKB1, LKB1 (T189A), LKB1 (S334A) or LKB1 (S428A), using Phospho-LKB1 (Thr189) Antibody .

Phospho-LKB1 (Ser334) Antibody - 3055 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, untransfected or transfected with Wild-type LKB1, LKB1 (T189A), LKB1 (S334A) or LKB1 (S428A), using Phospho-LKB1 (Ser334) Antibody .

LKB1 (D60C5) Rabbit mAb - 3047 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D60C5
Western blot analysis of extracts from various cell lines using LKB1 (D60C5) Rabbit mAb.

LKB1 (D60C5F10) Rabbit mAb (IHC Formulated) - 13031 from Cell Signaling Technology

Prices $99.00, $250.00
Sizes 20 µl (2 western blots), 100 µl (250 slides)
Host Rabbit
Clonality Monoclonal
Clone D60C5F10
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using LKB1 (D60C5F10) Rabbit mAb (IHC Formulated).

LKB1 (27D10) Rabbit mAb - 3050 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 27D10
Western blot analysis of extracts from Caki-1 and COS cells using LKB1 (27D10) Rabbit mAb.

Phospho-LKB1 (Ser428) Antibody - 3051 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

LKB1 Antibody - 3052 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

LKB1 (C-20) - sc-8184 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LKB1 (C-20): sc-8184. Western blot analysis of LKB1 expression in A-431 whole cell lysate.

LKB1 (E-9) - sc-374334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LKB1 (E-9): sc-374334. Western blot analysis of LKB1 expression in Jurkat whole cell lysate (A) and human kidney tissue extract (B).

LKB1 (G-12) - sc-374300 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LKB1 (G-12): sc-374300. Western blot analysis of LKB1 expression in A-431 (A) and 3611-RF (B) whole cell lysates.

LKB1 (D-19) - sc-5638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LKB1 (D-19): sc-5638. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

LKB1 (N-19) - sc-8185 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LKB1 (N-19): sc-8185. Western blot analysis of LKB1 expression in A-431 whole cell lysate.

LKB1 (H-3) - sc-374324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LKB1 (H-3): sc-374324. Western blot analysis of LKB1 expression in Jurkat whole cell lysate (A) and human kidney tissue extract (B).

LKB1 (H-75) - sc-28788 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LKB1 (H-75): sc-28788. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

LKB1 (Ley 37D/G6) - sc-32245 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LKB1 (Ley 37D/G6): sc-32245. Western blot analysis of LKB1 expression in 3611-RF whole cell lysate.

LKB1 (T-22) - sc-133742 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
LKB1 (T-22): sc-133742. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human muscle tissue showing cytoplasmic localization.

p-LKB1 (C-1) - sc-271924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of LKB1 phosphorylation in untreated (A,C) and lambda protein phosphatase (sc-200312A) treated (B,D) Caki-1 whole cell lysates. Antibodies tested include p-LKB1 (C-1): sc-271924 (A,B) and LKB1 (Ley 37D/G6): sc-32245 (C,D).

Anti-LKB1 (phospho S428) antibody - ab63473 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LKB1 (phospho S428) antibody (ab63473) at 1/500 dilutionLane 1 : mouse brain extractsLane 2 : mouse brain extracts with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-LKB1 (phospho S428) antibody - C-terminal - ab138386 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labelling LKB1 (phospho S428) with ab138386 at 1/50.

Anti-LKB1 (phospho T189) antibody - ab60987 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LKB1 (phospho T189) antibody (ab60987) at 1/500 dilutionLane 1 : Extracts from NIH/3T3 cells, treated with PMA (125ng/ml, 30mins).Lane 2 : Extracts from NIH/3T3 cells, treated with PMA (125ng/ml, 30mins) with immunizing phosphopeptide

Anti-LKB1 antibody - ab79355 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LKB1 antibody (ab79355) at 1/500 dilutionLane 1 : extracts from HT-29 cells at 10 µgLane 2 : extracts from HT-29 cells at 10 µg/ml with immunizing peptide at 10 µg

Anti-LKB1 antibody - ab50183 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LKB1 antibody - ab61122 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LKB1 antibody (ab61122) at 1/500 dilutionLane 1 : Extracts from HeLa cells treated with Serum (20%, 15mins)Lane 2 : Extracts from HeLa cells treated with Serum (20%, 15mins) with immunising LKB1 peptide

Anti-LKB1 antibody - ab63617 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of NIH/3T3 cells, using ab63617 at a dilution of 1/500-1/1000. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.
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