STK11
| Gene Symbol | STK11 |
|---|---|
| Entrez Gene | 6794 |
| Alt Symbol | LKB1, PJS, hLKB1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | serine/threonine kinase 11 |
| Other Description | liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11 |
| Swissprots | E7EW76 Q15831 B2RBX7 |
| Accessions | AAB97833 AAC15742 AAF97257 EAW69538 EAW69539 EAW69540 Q15831 AB209553 BAD92790 AF035625 AAC39527 AF217978 AAG17221 AJ844634 CAH59749 AK128518 AK314858 BAG37374 BC007981 AAH07981 BC019334 AAH19334 BM993274 BQ222023 BU174122 BU739451 DQ893232 ABM84158 DQ896561 ABM87560 EF644172 ABR45718 GU573916 ADD71158 U63333 AAB05809 XM_005259617 XP_005259674 XM_005259618 XP_005259675 XM_011528209 XP_011526511 XR_936204 NM_000455 NP_000446 |
| Function | Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA d |
| Subcellular Location | Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed. Strongest expression in testis and fetal liver. |
| Top Pathways | Adipocytokine signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, mTOR signaling pathway |
STK11-Over-expression-Lysate - LY10170a from Abgent, a WuXi AppTec company
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STK11 293T Cell Transient Overexpression Lysate(Denatured) - H00006794-T01 from Acris Antibodies
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STK11 overexpression lysate - LY424705 from Acris Antibodies
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STK11 293 Cell Lysate - 410222 from ABBIOTEC
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LKB1/STK11 Overexpression Lysate (Denatured) - H00006794-T01 from Novus Biologicals
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LKB1/STK11 Overexpression Lysate (Native) - NBL1-16540 from Novus Biologicals
![Western Blot: LKB1 Overexpression Lysate (Adult Normal) [NBL1-16540] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LKB1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6242_LKB1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16540-img0002.jpg)
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STK11 Over-expression Lysate Product - GWB-8EE384 from Genway Biotech
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STK11-knockout Cell lysate - LC810231 from Acris Antibodies
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Panoply™ Human STK11 Knockdown Stable Cell Line - CSC-DC015303 from Creative biogene
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Human STK11 Knockout Cell Line-HEK293T - CSC-RT0658 from Creative biogene
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Human STK11 Knockout Cell Line-HEK293T - CSC-RT1459 from Creative biogene
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STK11 KO Cell Lysate-HEK293T - CLKO-0164 from Creative biogene
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STK11 KO Cell Lysate-HEK293T - CLKO-1309 from Creative biogene
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