STK11

Gene Symbol	STK11
Entrez Gene	6794
Alt Symbol	LKB1, PJS, hLKB1
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 11
Other Description	liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11
Swissprots	E7EW76 Q15831 B2RBX7
Accessions	AAB97833 AAC15742 AAF97257 EAW69538 EAW69539 EAW69540 Q15831 AB209553 BAD92790 AF035625 AAC39527 AF217978 AAG17221 AJ844634 CAH59749 AK128518 AK314858 BAG37374 BC007981 AAH07981 BC019334 AAH19334 BM993274 BQ222023 BU174122 BU739451 DQ893232 ABM84158 DQ896561 ABM87560 EF644172 ABR45718 GU573916 ADD71158 U63333 AAB05809 XM_005259617 XP_005259674 XM_005259618 XP_005259675 XM_011528209 XP_011526511 XR_936204 NM_000455 NP_000446
Function	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA d
Subcellular Location	Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Strongest expression in testis and fetal liver.
Top Pathways	Adipocytokine signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LKB1 CRISPR/Cas9 KO Plasmid (h) - sc-400313 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 HDR Plasmid (h) - sc-400313-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 Double Nickase Plasmid (h) - sc-400313-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 Double Nickase Plasmid (h2) - sc-400313-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 CRISPR Activation Plasmid (h) - sc-400313-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 CRISPR Activation Plasmid (h2) - sc-400313-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 Lentiviral Activation Particles (h) - sc-400313-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 Lentiviral Activation Particles (h2) - sc-400313-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

LKB1 siRNA (h) - sc-35816 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LKB1 shRNA Plasmid (h) - sc-35816-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LKB1 shRNA (h) Lentiviral Particles - sc-35816-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

LKB1/STK11 RNAi - H00006794-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU019041 from Sigma-Aldrich Category siRNA

MISSION® siRNA - SIHK2135 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2136 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2137 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1714 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1714 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

STK11 siRNA (Human) - CRH4649 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK11 - MBS827588 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human STK11 (NM_000455.4) - SHH419688 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human STK11(NM_000455.4) - SHL034086 from Creative biogene Category siRNA Species Reactivities Human

Human STK11 siRNA - orb265151 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

STK11 shRNA Plasmid (Human) - CHH4649 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

STK11 miRNA 3'UTR clone - MiUTR1H-10001 from Creative biogene Species Reactivities Human

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