STK11

Gene Symbol	STK11
Entrez Gene	6794
Alt Symbol	LKB1, PJS, hLKB1
Species	Human
Gene Type	protein-coding
Description	serine/threonine kinase 11
Other Description	liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11
Swissprots	E7EW76 Q15831 B2RBX7
Accessions	AAB97833 AAC15742 AAF97257 EAW69538 EAW69539 EAW69540 Q15831 AB209553 BAD92790 AF035625 AAC39527 AF217978 AAG17221 AJ844634 CAH59749 AK128518 AK314858 BAG37374 BC007981 AAH07981 BC019334 AAH19334 BM993274 BQ222023 BU174122 BU739451 DQ893232 ABM84158 DQ896561 ABM87560 EF644172 ABR45718 GU573916 ADD71158 U63333 AAB05809 XM_005259617 XP_005259674 XM_005259618 XP_005259675 XM_011528209 XP_011526511 XR_936204 NM_000455 NP_000446
Function	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA d
Subcellular Location	Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Strongest expression in testis and fetal liver.
Top Pathways	Adipocytokine signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LKB1 full length protein - ab119736 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human LKB1 full length protein - ab202187 from Abcam Category Protein Source E. coli Species Human

Human LKB1 peptide - ab97366 from Abcam Category Peptide

STK11 / LKB1 Antibody Blocking Peptide - LS-E4927 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK11 / LKB1 Antibody Blocking Peptide - LS-E30290 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

STK11 / LKB1 Antibody Blocking Peptide - LS-E8791 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK11 / LKB1 Antibody Blocking Peptide - LS-E8792 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK11 / LKB1 Antibody Blocking Peptide - LS-E21573 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK11 / LKB1 Antibody Blocking Peptide - LS-E15358 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STK11 / LKB1 Blocking Peptide - LS-E15359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LKB1/STK11 Protein - H00006794-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

LKB1/STK11 Partial Recombinant Protein - H00006794-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

LKB1/STK11 Peptide - NBP1-76402PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

STK11-LKB1-Antibody-N-term-V34-Blocking-peptide - BP7239d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STK11-LKB1-Antibody-N-term-I29-Blocking-peptide - BP7239a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human STK11 protein - orb244832 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

LKB1 Peptide - orb224215 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

STK11 peptide - orb217985 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse

LKB1 Blocking Peptide - 33R-11022 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

STK11 Blocking Peptide - 33R-9160 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

STK11 Blocking Peptide - 33R-2273 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

STK11 protein (His tag) - 80R-4086 from Fitzgerald Category Protein Prices $275.00 Sizes 50 µg Source E.coli

LKB1 (phospho-Ser428) Blocking Peptide - abx063316 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

STK11 (1-433, His-tag) - AR51772PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

STK11 (1-433, His-tag) - AR51772PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 50 µg Source E. coli Species Human

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