Gene Symbol | STK11 |
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Entrez Gene | 6794 |
Alt Symbol | LKB1, PJS, hLKB1 |
Species | Human |
Gene Type | protein-coding |
Description | serine/threonine kinase 11 |
Other Description | liver kinase B1|polarization-related protein LKB1|renal carcinoma antigen NY-REN-19|serine/threonine-protein kinase 11|serine/threonine-protein kinase LKB1|serine/threonine-protein kinase STK11 |
Swissprots | E7EW76 Q15831 B2RBX7 |
Accessions | AAB97833 AAC15742 AAF97257 EAW69538 EAW69539 EAW69540 Q15831 AB209553 BAD92790 AF035625 AAC39527 AF217978 AAG17221 AJ844634 CAH59749 AK128518 AK314858 BAG37374 BC007981 AAH07981 BC019334 AAH19334 BM993274 BQ222023 BU174122 BU739451 DQ893232 ABM84158 DQ896561 ABM87560 EF644172 ABR45718 GU573916 ADD71158 U63333 AAB05809 XM_005259617 XP_005259674 XM_005259618 XP_005259675 XM_011528209 XP_011526511 XR_936204 NM_000455 NP_000446 |
Function | Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA d |
Subcellular Location | Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. Strongest expression in testis and fetal liver. |
Top Pathways | Adipocytokine signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, mTOR signaling pathway |
Mouse/Human Phospho-STK11 / LKB1 (Ser428) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1255 from LifeSpan Bioscience
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Mouse/Human Phospho-STK11 / LKB1 (Thr189) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1256 from LifeSpan Bioscience
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Mouse/Human STK11 / LKB1 ELISA Kit (Cell-Based ELISA) - LS-F2119 from LifeSpan Bioscience
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Mouse STK11 / LKB1 ELISA Kit (Sandwich ELISA) - LS-F9657 from LifeSpan Bioscience
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Serine/threonine-protein kinase 11 (STK11), Human, ELISA Kit - E01S0409 from ARP American Research Products
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Serine/threonine-protein kinase STK11, STK11, Human, ELISA Kit - E13097h from ARP American Research Products
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LKB1 Colorimetric Cell-Based ELISA Kit - CB5418 from Assay Biotechnology
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LKB1 (Phospho-Ser428) Colorimetric Cell-Based ELISA Kit - CBP1255 from Assay Biotechnology
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LKB1 (Phospho-Thr189) Colorimetric Cell-Based ELISA Kit - CBP1256 from Assay Biotechnology
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Serine/Threonine Kinase 11, ELISA Kit - MBS064768 from MyBioSource
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Serine/Threonine Kinase 11, ELISA Kit - MBS100610 from MyBioSource
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Serine/Threonine Kinase 11, ELISA Kit - MBS053056 from MyBioSource
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Serine/Threonine Kinase 11, ELISA Kit - MBS084561 from MyBioSource
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Serine/Threonine Kinase 11, ELISA Kit - MBS083369 from MyBioSource
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Serine/Threonine Kinase 11, ELISA Kit - MBS055245 from MyBioSource
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Serine/Threonine Kinase 11, ELISA Kit - MBS104413 from MyBioSource
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Serine/Threonine Kinase 11 (STK11), ELISA Kit - MBS2000239 from MyBioSource
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ELISA Kit for Serine/Threonine Kinase 11 (STK11) - SEH115Mu from Uscn Life Science Inc.
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Chicken STK11 / LKB1 ELISA Kit (Custom ELISA) - LS-F16839 from LifeSpan Bioscience
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Human STK11 / LKB1 ELISA Kit (Custom ELISA) - LS-F16838 from LifeSpan Bioscience
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Mouse STK11 / LKB1 ELISA Kit (Custom ELISA) - LS-F16840 from LifeSpan Bioscience
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Rat STK11 / LKB1 ELISA Kit (Sandwich ELISA) - LS-F13457 from LifeSpan Bioscience
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LKB1 ELISA Kit - DEIA-XYA1138 from Creative Diagnostics
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LKB1 (Phospho-Ser428) ELISA Kit - DEIA-XYA1139 from Creative Diagnostics
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LKB1 (Phospho-Thr189) ELISA Kit - DEIA-XYA1140 from Creative Diagnostics
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