HGS

Gene Symbol HGS
Entrez Gene 9146
Alt Symbol HRS
Species Human
Gene Type protein-coding
Description hepatocyte growth factor-regulated tyrosine kinase substrate
Other Description human growth factor-regulated tyrosine kinase substrate|protein pp110
Swissprots O14964 Q9NR36
Accessions EAW89675 EAW89676 EAW89677 EAW89678 EAW89679 O14964 AF260566 AAF82361 AI365104 AK021483 AK097197 AK294190 BAG57506 AK303800 BAG64754 BC003565 AAH03565 BT009754 AAP88756 D84064 BAA23366 DQ892551 ABM83477 DQ895762 ABM86688 DR001213 U43895 AAC51929 XM_005257794 XP_005257851 XM_011525463 XP_011523765 XM_011525464 XP_011523766 NM_004712 NP_004703
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation
Subcellular Location Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. {ECO:0000269|PubMed:9407053, ECO:0000269|PubMed:9630564}.
Top Pathways Endocytosis, Phagosome

Mouse/Human/Rat HRS / HGS ELISA Kit (Cell-Based ELISA) - LS-F2048 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 23.438-1500 pg/ml

Mouse/Human/Rat Phospho-HRS / HGS (Tyr334) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1392 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 23.438-1500 pg/ml

HGS Colorimetric Cell-Based ELISA Kit - CB5331 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

HRS (Phospho-Tyr334) Colorimetric Cell-Based ELISA Kit - CBP1412 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Human HGS(Hepatocyte growth factor-regulated tyrosine kinase substrate) ELISA Kit - E-EL-H5467 from Elabscience

Category ELISA Kit
Sensitivity 9.38 pg/mL
Range 15.63—1000 pg/mL

hepatocyte growth factor-regulated tyrosine kinase substrate, ELISA Kit - MBS913164 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human HGS is typically less than 5.86 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 23.44 pg/ml -1500 pg/ml.

Human Hepatocyte growth factor-regulated tyrosine kinase substrate(HGS) ELISA ki - CSB-EL010329HU from Cusabio

Sensitivity 5.86pg/ml
Range 23.44 pg/ml-1500 pg/ml

Human HGS(Hepatocyte growth factor-regulated tyrosine kinase substrate) ELISA Kit - E-EL-H5467 from Iwai North America Inc.

Category ELISA Kit
Prices $580.00
Sizes 1 kit
Sensitivity 9.38 pg/mL
Range 15.63~1000 pg/mL

HGS ELISA Kit - DEIA-XYA791 from Creative Diagnostics

Category ELISA Kit

Human Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) ELISA Kit - EKC34002 from Biomatik

Category ELISA Kit
Prices $705.00, $2,820.00, $5,288.00
Sizes 96 t, 5x96t, 10x96t
Sensitivity 5.86 pg/ml
Range 23.44 pg/ml-1500 pg/ml

Human HGS ELISA Kit - E018394 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human HGS is typically less than 5.86 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

HGS ELISA Kit (Human) (OKCA01285) - OKCA01285 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 5.86 pg/mL
Range 23.44 - 1,500 pg/mL

HGS (Hepatocyte growth factor-regulated tyrosine kinase substrate), ELISA Kit - MBS7606482 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 14.063pg/ml
Range 23.438-1500pg/ml

Human HRS / HGS ELISA Kit (Sandwich ELISA) - LS-F38121 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 9.375
Range 23.438-1500 pg/ml

Human HRS / HGS ELISA Kit (Sandwich ELISA) - LS-F31922 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 14.063
Range 23.438-1500 pg/ml

Human HGS ELISA Kit - orb404550 from Biorbyt

Category ELISA Kit
Sensitivity 5.86pg/ml
Range 23.44 pg/ml-1500 pg/ml

HGS Colorimetric Cell-Based ELISA Kit - EKA50283 from Biomatik

Category ELISA Kit
Prices $399.00
Sizes 96 tests
Sensitivity At least 5000 cells/well
Range Qualitative
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