| Gene Symbol |
HGS
|
| Entrez Gene |
9146
|
| Alt Symbol |
HRS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hepatocyte growth factor-regulated tyrosine kinase substrate
|
| Other Description |
human growth factor-regulated tyrosine kinase substrate|protein pp110
|
| Swissprots |
O14964 Q9NR36
|
| Accessions |
EAW89675 EAW89676 EAW89677 EAW89678 EAW89679 O14964 AF260566 AAF82361 AI365104 AK021483 AK097197 AK294190 BAG57506 AK303800 BAG64754 BC003565 AAH03565 BT009754 AAP88756 D84064 BAA23366 DQ892551 ABM83477 DQ895762 ABM86688 DR001213 U43895 AAC51929 XM_005257794 XP_005257851 XM_011525463 XP_011523765 XM_011525464 XP_011523766 NM_004712 NP_004703
|
| Function |
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation
|
| Subcellular Location |
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. {ECO:0000269|PubMed:9407053, ECO:0000269|PubMed:9630564}.
|
| Top Pathways |
Endocytosis, Phagosome
|