HGS

Gene Symbol	HGS
Entrez Gene	9146
Alt Symbol	HRS
Species	Human
Gene Type	protein-coding
Description	hepatocyte growth factor-regulated tyrosine kinase substrate
Other Description	human growth factor-regulated tyrosine kinase substrate|protein pp110
Swissprots	O14964 Q9NR36
Accessions	EAW89675 EAW89676 EAW89677 EAW89678 EAW89679 O14964 AF260566 AAF82361 AI365104 AK021483 AK097197 AK294190 BAG57506 AK303800 BAG64754 BC003565 AAH03565 BT009754 AAP88756 D84064 BAA23366 DQ892551 ABM83477 DQ895762 ABM86688 DR001213 U43895 AAC51929 XM_005257794 XP_005257851 XM_011525463 XP_011523765 XM_011525464 XP_011523766 NM_004712 NP_004703
Function	Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation
Subcellular Location	Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. {ECO:0000269|PubMed:9407053, ECO:0000269|PubMed:9630564}.
Top Pathways	Endocytosis, Phagosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HGS full length protein - ab132524 from Abcam Category Protein Source Wheat germ Species Human

Human HGS peptide - ab48060 from Abcam Category Peptide Species Human

Human HGS protein fragment - ab152956 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human HGS Protein - H00009146-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HGS Protein - H00009146-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HGS Peptide - P0972 from Novus Biologicals Category Peptide Species Human

HGS Peptide - P0971 from Novus Biologicals Category Peptide Species Human

IMOS-1-Antibody-Center-Blocking-Peptide - BP2161c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HGS-Antibody-N-term-Blocking-Peptide - BP2161a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HGS blocking peptide - GTX89364-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

HGS Peptide - AC21-0906-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HGS / HRS - H00009146-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HGS / HRS - H00009146-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HGS / HRS - H00009146-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HGS / HRS - H00009146-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HRS Peptide - 45-746P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

HGS fusion protein - Ag0589 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human HGS, GST-tagged - HGS-13762H from Creative Biomart Category Protein Source E.coli Species Human

HGS Blocking Peptide - CBP3365 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Pig

Hrs (L330) Peptide - BS1666P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Hrs (R481) Peptide - BS2448P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-Hrs (Y216) Peptide - BS4824P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Hepatocyte growth factor-regulated tyrosine kinase substrate(H - CSB-YP010329HU CSB-EP010329HU CSB-BP010329HU CSB-MP010329HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HGS / HRS - TP300609 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HRS/HGS, Peptide - MBS425584 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

Search more