HGS

Gene Symbol	HGS
Entrez Gene	9146
Alt Symbol	HRS
Species	Human
Gene Type	protein-coding
Description	hepatocyte growth factor-regulated tyrosine kinase substrate
Other Description	human growth factor-regulated tyrosine kinase substrate|protein pp110
Swissprots	O14964 Q9NR36
Accessions	EAW89675 EAW89676 EAW89677 EAW89678 EAW89679 O14964 AF260566 AAF82361 AI365104 AK021483 AK097197 AK294190 BAG57506 AK303800 BAG64754 BC003565 AAH03565 BT009754 AAP88756 D84064 BAA23366 DQ892551 ABM83477 DQ895762 ABM86688 DR001213 U43895 AAC51929 XM_005257794 XP_005257851 XM_011525463 XP_011523765 XM_011525464 XP_011523766 NM_004712 NP_004703
Function	Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down- regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation
Subcellular Location	Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes. {ECO:0000269|PubMed:9407053, ECO:0000269|PubMed:9630564}.
Top Pathways	Endocytosis, Phagosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Hrs CRISPR/Cas9 KO Plasmid (h) - sc-401501 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs HDR Plasmid (h) - sc-401501-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs Double Nickase Plasmid (h) - sc-401501-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs Double Nickase Plasmid (h2) - sc-401501-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs CRISPR Activation Plasmid (h) - sc-401501-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs CRISPR Activation Plasmid (h2) - sc-401501-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs Lentiviral Activation Particles (h) - sc-401501-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs Lentiviral Activation Particles (h2) - sc-401501-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Hrs siRNA (h) - sc-41232 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Hrs shRNA Plasmid (h) - sc-41232-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Hrs shRNA (h) Lentiviral Particles - sc-41232-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HGS RNAi - H00009146-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HGS RNAi - H00009146-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU074591 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10013 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10013 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

HGS siRNA (Human) - CRH6052 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HGS - MBS828113 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human HGS (NM_004712.4) - SHH311933 from Creative biogene Category siRNA Species Reactivities Human

Hrs siRNA (h2) - sc-270003 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Hrs shRNA Plasmid (h2) - sc-270003-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Hrs shRNA (h2) Lentiviral Particles - sc-270003-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Human HGS siRNA - orb266554 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HGS shRNA Plasmid (Human) - CHH6052 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

HGS miRNA 3'UTR clone - MiUTR3H-06760 from Creative biogene Species Reactivities Human

Search more