TLR3

Gene Symbol TLR3
Entrez Gene 7098
Alt Symbol CD283, IIAE2
Species Human
Gene Type protein-coding
Description toll-like receptor 3
Other Description -
Swissprots Q4VAL2 E9PGH4 E6Y0F1 Q504W0 E6Y0F0 B2RAI7 O15455 B7Z7K0
Accessions ABC86908 ABC86909 ABC86910 CAL68868 CAT16976 EAX04628 EAX04629 O15455 AB445631 BAG55028 AK302143 BAH13636 AK314208 BAG36884 BC017954 BC043204 BC059372 AAH59372 BC068487 BC094737 AAH94737 BC096333 AAH96333 BC096334 AAH96334 BC096335 AAH96335 BU624267 DA374150 DQ445682 ABE01399 DQ470075 ABF06633 DQ470076 ABF06634 DQ470077 ABF06635 DQ470078 ABF06636 DQ470079 ABF06637 U88879 AAC34134 NM_003265 NP_003256
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.
Tissue Specificity Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. {ECO:0000269|PubMed:17085778}.
Top Pathways Toll-like receptor signaling pathway, Hepatitis C, Influenza A, Herpes simplex infection

Toll-like Receptor 3 (D10F10) Rabbit mAb - 6961 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10F10
Western blot analysis of extracts from MCF 10A cells, transfected with 100 nM SignalSilence® Control siRNA (Unconjugated) #6568 (-) or SignalSilence® Toll-like Receptor 3 siRNA I #6236 (+), using Toll-like Receptor 3 (D10F10) Rabbit mAb #6961 (upper) or α-Tubulin (11H10) Rabbit mAb #2125 (lower). The Toll-like Receptor 3 (D10F10) Rabbit mAb confirms silencing of Toll-like Receptor 3 expression, while the α-Tubulin (11H10) Rabbit mAb is used as a loading control.

Toll-like Receptor 3 Antibody - 2253 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 and BaF3 cell lines, using Toll-like Receptor 3 Antibody.

TLR3 (H-125) - sc-10740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TLR3 siRNA (h): sc-36685. Western blot analysis of TLR3 expression in non-transfected control (A) and TLR3 siRNA transfected (B) HeLa cells. Blot probed with TLR3 (H-125): sc-10740. α-actinin (H-2): sc-17829 used as specificity and loading control.

TLR3 (L-13) - sc-16238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR3 (M-300) - sc-28999 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TLR3 (M-300): sc-28999. Western blot analysis of TLR3 expression in HeLa (A) and human PBL (B) whole cell lysates.

TLR3 (N-14) - sc-8691 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLR3 (N-14): sc-8691. Western blot analysis of TLR3 expression in COLO 320DM (A), CCRF-HSB-2 (B) and NAMALWA (C) whole cell lysates.

TLR3 (T-17) - sc-23323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR3 (Q-18) - sc-12509 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TLR3 (Q-18): sc-12509. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing membrane and cytoplasmic staining of urothelial cells.

TLR3 (TLR3.7) - sc-32232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TLR3 (C-20) - sc-8692 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TLR3 (40C1285) - sc-52961 from Santa Cruz Biotechnology

Anti-TLR3 antibody - ab62566 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TLR3 antibody (ab62566) at 1 µg/mlLane 2 : Anti-TLR3 antibody (ab62566) at 2 µg/mlLane 1 : Daudi cell lysateLane 2 : Daudi cell lysateLysates/proteins at 15 µg per lane.

Anti-TLR3 antibody - ab62567 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TLR3 antibody (ab62567) at 0.5 µg/mlLane 2 : Anti-TLR3 antibody (ab62567) at 1 µg/mlLane 3 : Anti-TLR3 antibody (ab62567) at 2 µg/mlLane 1 : K562 cell lysateLane 2 : K562 cell lysateLane 3 : K562 cell lysateLysates/proteins at 15 µg per lane.

Anti-TLR3 antibody - ab83338 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of TLR3 staining in mouse kidney formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab83338, 5µg/ml, for 15 mins at room temperature. A goat anti rabbit biotinylated secondary antibody was used to detect the primary, and visualized using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-TLR3 antibody - ab84911 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TLR3 antibody (ab84911) at 1 µg/ml + Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TLR3 antibody - ab14076 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-TLR3 antibody [40C1285] - ab13915 from Abcam

Prices $369.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 40C1285

Anti-TLR3 antibody [40C1285.6] (FITC) - ab45053 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 40C1285.6
Intracellular flow cytometric analysis of TLR3 (open peak) and isotype negative control (shaded peak) on Ramos cells using ab45053 at 3 ug/106 cells.

Anti-TLR3 antibody [40C1285.6] (Phycoerythrin) - ab45093 from Abcam

Prices $387.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 40C1285.6
All lanes : Anti-TLR3 antibody [40C1285.6] (Phycoerythrin) (ab45093) at 1 µg/mlLane 1 : A459 cell lysateLane 2 : Human skin tissue lysateLane 3 : Human lung tissue lysateLane 4 : Human dendritic cell lysateLane 5 : Human macrophage cell lysateLysates/proteins at 15 µg per lane.SecondaryHRP-conjugated Goat anti-mouse IgG at 1/2000 dilutionPerformed under reducing conditions.

Anti-TLR3 antibody [TLR3.7] - ab12085 from Abcam

Prices $379.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone TLR3.7

Anti-TLR3 antibody [TLR3.7] (Biotin) - ab17264 from Abcam

Prices $379.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone TLR3.7

Anti-TLR3 antibody [TLR3.7] - Low endotoxin, Azide free - ab174604 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TLR3.7
Flow cytometric analysis of permeabilized A549 cells labeling TLR3 with ab174604 at 1μg (filled histogram) compared with a Mouse IgG1 K Isotype Control at 1 µg (open histogram) followed by Anti-Mouse IgG FITC. Total cells were used for analysis.

Anti-TLR3 antibody - Aminoterminal end - ab59918 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ab59918 at a dilution of 1/50. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

Anti-TLR3 antibody - Carboxyterminal end - ab59919 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with ab59919 at a dilution of 1/50. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

Anti-TLR3 Antibody (clone 40C1285, FITC) - LS-C10691 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 40C1285
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