TLR3

Gene Symbol	TLR3
Entrez Gene	7098
Alt Symbol	CD283, IIAE2
Species	Human
Gene Type	protein-coding
Description	toll-like receptor 3
Other Description	-
Swissprots	Q4VAL2 E9PGH4 E6Y0F1 Q504W0 E6Y0F0 B2RAI7 O15455 B7Z7K0
Accessions	ABC86908 ABC86909 ABC86910 CAL68868 CAT16976 EAX04628 EAX04629 O15455 AB445631 BAG55028 AK302143 BAH13636 AK314208 BAG36884 BC017954 BC043204 BC059372 AAH59372 BC068487 BC094737 AAH94737 BC096333 AAH96333 BC096334 AAH96334 BC096335 AAH96335 BU624267 DA374150 DQ445682 ABE01399 DQ470075 ABF06633 DQ470076 ABF06634 DQ470077 ABF06635 DQ470078 ABF06636 DQ470079 ABF06637 U88879 AAC34134 NM_003265 NP_003256
Function	Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.
Tissue Specificity	Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. {ECO:0000269|PubMed:17085778}.
Top Pathways	Toll-like receptor signaling pathway, Hepatitis C, Influenza A, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TLR3 protein fragment - ab73825 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source HEK 293 cells Species Human

Human TLR3 protein fragment - ab159716 from Abcam Category Protein Source Wheat germ Species Human

TLR3 peptide - ab125950 from Abcam Category Peptide

TLR3 peptide - ab93752 from Abcam Category Peptide

TLR3 peptide - ab93793 from Abcam Category Peptide

TLR3 Antibody Blocking Peptide - LS-E30189 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TLR3 Antibody Blocking Peptide - LS-E30190 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Human TLR3 Protein - NBP2-36592 from Novus Biologicals Category Protein Prices $175.00 Sizes 50 µg Species Human

Human TLR3 Biologically Active Protein - NBP2-36506 from Novus Biologicals Category Protein Prices $169.00 Sizes 50 µg Source Mouse myeloma cell line, NS0 Species Human

TLR3 Partial Recombinant Protein - H00007098-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TLR3 Blocking Peptide - NBP1-76660PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TLR3 Blocking Peptide - NBP1-76659PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TLR3 Peptide - P0506 from Novus Biologicals Category Peptide Species Human

TLR3-Antibody-N-term-Blocking-Peptide - BP1503b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TLR3 Recombinant Protein (Active) - GTX48122-PRO from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source Human Species Human

Recombinant Human TLR3, CF - 1487-TR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Lys27-Ser711, with a C-terminal 10-His tag

TLR3 peptide - orb73278 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

TLR3 Blocking Peptide - 33R-10763 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

TLR3 Blocking Peptide - 33R-10492 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

TLR3 protein - 30R-AT071 from Fitzgerald Category Protein Prices $225.00 Sizes 25 µg Source 293 cells

Human Toll Like Receptor 3 Protein - abx069361 from Abbexa Category Protein Source E.coli Species Human

CD283 / TLR3 - AR31102PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 25 µg Source HEK293 cells Species Human

CD283 / TLR3 - AR31102PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source HEK293 cells Species Human

CD283 / TLR3 - H00007098-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD283 / TLR3 - H00007098-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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